FREQUENT LOSS OF HETEROZYGOSITY ON CHROMOSOME-16 AND CHROMOSOME-4 IN HUMAN HEPATOCELLULAR-CARCINOMA

被引：142

作者：

ZHANG, WD

HIROHASHI, S

TSUDA, H

SHIMOSATO, Y

YOKOTA, J

TERADA, M

SUGIMURA, T

机构：

[1] NATL CANC CTR,RES INST,DIV PATHOL,5-1-1 TSUKIJI,CHUO KU,TOKYO 104,JAPAN

[2] NATL CANC CTR,RES INST,STUDIES CANC METASTASIS SECT,CHUO KU,TOKYO 104,JAPAN

[3] NATL CANC CTR,RES INST,DIV GENET,CHUO KU,TOKYO 104,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1990年 / 81卷 / 02期

关键词：

Human hepatocellular carcinoma; Restriction fragment length polymorphism;

D O I：

10.1111/j.1349-7006.1990.tb02534.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

By restriction fragment length polymorphism analysis, we examined loss of heterozygosity at 34 loci on 23 chromosomes in 35 surgically resected human hepatocellular carcinomas. Allele losses at the HP locus on chromosome 16q22 and at the MT2P1 locus on chromosome 4p11‐q21 were detected in 57% (8/14) and 50% (8/16) of cases, respectively. Loss of heterozygosity on chromosomes 16q and 4 occurred simultaneously in 4 of 7 informative cases for both loci, and seemed to be important in the development of human hepatocellular carcinoma irrespective of the presence of hepatitis B virus infection. In contrast, the incidence of allele loss was low at the other loci, e.g., chromosome 1p, 3p, 11p, 13q or 17p, where one allele is frequently lost in other cancers. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：108 / 111

页数：4

共 18 条

[1]

BUETOW K H, 1987, American Journal of Human Genetics, V41, pA24

[2] ISOLATION OF POLYMORPHIC DNA FRAGMENTS FROM HUMAN CHROMOSOME-4 [J].