RELATIONSHIP OF BUTAPERAZINE BLOOD-LEVELS TO PLASMA PROLACTIN IN CHRONIC-SCHIZOPHRENIC PATIENTS

被引：7
作者：
SMITH, RC
TAMMINGA, CA
CRAYTON, JW
DEKIRMENJIAN, H
DAVIS, JM
机构：
[1] MANTENO MENTAL HLTH CTR,MANTENO,IL
[2] BAYLOR UNIV,COLL MED,DEPT PHARMACOL,HOUSTON,TX 77025
[3] UNIV CHICAGO,DEPT PSYCHIAT,CHICAGO,IL 60637
[4] ILLINOIS STATE PSYCHIAT INST,CHICAGO,IL 60612
[5] NIMH,BETHESDA,MD 20014
[6] NATL PSYCHOPHARMACOL LAB,KNOXVILLE,TN
来源：
PSYCHOPHARMACOLOGY | 1979年 / 66卷 / 01期
关键词：
Blood levels; Butaperazine; Prolactin;
D O I：
10.1007/BF00431985
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The relationship of plasma prolactin to plasma or red blood cell butaperazine levels was investigated in chronic schizophrenic patients treated with clinical doses of butaperazine, both after a single acute dose of the drug and during regular, twice daily butaperazine administration. Although there was a significant curvilinear relationship between peak plasma butaperazine levels after an acute single oral dose of butaperazine and the maximum prolactin response that we measured, steady-state levels of plasma or red cell butaperazine and plasma prolactin were not related. We conclude that plasma prolactin cannot be used as a substitute for or even as a rough indicator of butaperazine blood levels in chronic schizophrenic patients being treated with clinical doses of butaperazine. © 1979 Springer-Verlag.
引用
收藏
页码：29 / 33
页数：5
相关论文
共 19 条
  • [1] BROWN GM, 1976, ENDOCRINOLOGY, V99, P1401
  • [2] ANTIPSYCHOTIC-DRUGS STIMULATE PROLACTIN-RELEASE
    CLEMENS, JA
    SMALSTIG, EB
    SAWYER, BD
    [J]. PSYCHOPHARMACOLOGIA, 1974, 40 (02): : 123 - 127
  • [3] DOPAMINE RECEPTOR-BINDING PREDICTS CLINICAL AND PHARMACOLOGICAL POTENCIES OF ANTI-SCHIZOPHRENIC DRUGS
    CREESE, I
    BURT, DR
    SNYDER, SH
    [J]. SCIENCE, 1976, 192 (4238) : 481 - 483
  • [4] DAVIS JM, 1974, ADV BIOCH PSYCHOPHAR, P433
  • [5] DEKIRMENJIAN H, CLIN CHEM ACTA
  • [6] LOSS OF CENTRAL NERVOUS-SYSTEM COMPONENT OF DOPAMINERGIC INHIBITION OF PROLACTIN SECRETION IN PATIENTS WITH PROLACTIN-SECRETING PITUITARY TUMORS
    FINE, SA
    FROHMAN, LA
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1978, 61 (04) : 973 - 980
  • [7] NEUROPHARMACOLOGIC CONTROL OF NEUROENDOCRINE FUNCTION IN MAN
    FROHMAN, LA
    STACHURA, ME
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1975, 24 (02): : 211 - 234
  • [8] GARVER DL, 1976, ARCH GEN PSYCHIAT, V33, P862
  • [9] GARVER DL, 1977, AM J PSYCHIAT, V134, P304
  • [10] GRUEN PH, 1978, ARCH GEN PSYCHIAT, V35, P108
12