MAST-CELL POPULATION-DENSITY, BLOOD-VESSEL DENSITY AND HISTAMINE CONTENT IN NORMAL HUMAN-SKIN

被引：146

作者：

EADY, RAJ ^{[1
]}

COWEN, T ^{[1
]}

MARSHALL, TF ^{[1
]}

PLUMMER, V ^{[1
]}

GREAVES, MW ^{[1
]}

机构：

[1] UNIV LONDON LONDON SCH HYG & TROP MED,DEPT MED STAT & EPIDEMIOL,LONDON WC1E 7HT,ENGLAND

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1979年 / 100卷 / 06期

关键词：

D O I：

10.1111/j.1365-2133.1979.tb08065.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Mast cell population density was determined in normal skin from two regions of the arm of several healthy men and compared with blood vessel density and histamine concentration in the same sites. Mast cell and hlood vessel counts were made in 1–1.5 μm thick plastic sections, by light microscopy and tissue‐histamine concentrations were determined by automated fluorimetric analysis. Statistically significant correlations were found between mast cell counts, blood vessel counts and histamine content in skin from the upper arm but no similar correlations were obtained in the forearm. Anatomical differences between the two sites may have been the cause of this discrepancy. Wide variations in mast cell counts and blood vessel density were found in different sections from the same biopsy samples which confirms the notion that dermal mast cells are imevenly distributed. Analysis of variance of the mast cell counts showed that the variance between sections from different blocks from the same biopsy samples was greater than the variance between adjacent biopsies. There was also a marked variation in the histamine content between biopsy samples from sites only 2 cm apart in the same subject. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：623 / 633

页数：11

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