SUBSTITUTED CYCLIC IMIDES AS POTENTIAL ANTIGOUT AGENTS

被引：66

作者：

HALL, IH

SCOVILLE, JP

REYNOLDS, DJ

SIMLOT, R

DUNCAN, P

机构：

[1] Division of Medicinal Chemistry, Natural Products School of Pharmacy, Chapel Hill, NC 27599

来源：

LIFE SCIENCES | 1990年 / 46卷 / 26期

关键词：

D O I：

10.1016/0024-3205(90)90507-N

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

N-substituted cyclic imides of phthalimide, 2,3-dihydrohalazine-1,4 4-dione, and diphenimide were shown to reduce the serum uric acid levels in normal and hyperuric mice at 20 mg/kg/day I.P. for 14 days. The agents were potent inhibitors of commercial xanthine dehydrogenase and xanthine oxidase enzyme activities with IC50 values from 10-7 to 10-8 M concentrations of drug. © 1990.

引用

页码：1923 / 1927

页数：5

共 9 条

[1]

BLUESTONE R, 1975, LAB INVEST, V33, P273

[2]

CHAPMAN JM, 1983, J MED CHEM, V28, P237

[3] METABOLIC STUDIES OF ALLOPURINOL AN INHIBITOR OF XANTHINE OXIDASE [J].

ELION, GB ;

KOVENSKY, A ;

HITCHING.GH ;

METZ, E ;

RUNDLES, RW .

BIOCHEMICAL PHARMACOLOGY, 1966, 15 (07) :863-&

[4]

FEIGELSON P, 1957, J BIOL CHEM, V226, P993

[5]

HALL IH, UNPUB ACTA PHARM NOR

[6]

MURTHY AR, 1985, EUR J MED CHEM, V20, P547

[7]

RUNDLES RW, 1963, T ASSOC AM PHYSICIAN, V76, P126

[8]

SCOVILLE JP, IN PRESS BIOCH BIOME

[9]

TIETZ NW, 1976, FUNDAMENTALS CLIN CH, P999

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