NEOPLASTIC AND NONNEOPLASTIC LESIONS IN AGING (C57BL-6NXC3H-HEN)F1 (B6C3F1) MICE

被引：188

作者：

WARD, JM ^{[1
]}

GOODMAN, DG ^{[1
]}

SQUIRE, RA ^{[1
]}

CHU, KC ^{[1
]}

LINHART, MS ^{[1
]}

机构：

[1] NCI,DIV CANC CAUSE & PREVENT,PROGRAM CARCINOGENESIS TESTING,INFORMAT & RESOURCES BRANCH,BETHESDA,MD 20205

来源：

JOURNAL OF THE NATIONAL CANCER INSTITUTE | 1979年 / 63卷 / 03期

关键词：

D O I：

10.1093/jnci/63.3.849

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neoplastic and nonneoplastlc lesions In untreated (C57BL/6N ×C3H/HeN)F1 (B6C3F1) mice used as controls In carcinogenesis tests were tabulated and evaluated. The most common neoplasms in 2,543 male mice were hepatocellular adenomas and carcinomas, lymphomas, leukemias, and pulmonary adenomas and carcinomas. In 2,522 female mice, common tumors were lymphomas, leukemias, pulmonary adenomas and carcinomas, hepatocellular adenomas and carcinomas, and pituitary adenomas. The risk of developing most neoplasms increased with the age of the mouse. Hepatocellular carcinomas metastasized in 12% of the animals with these tumors. Other than lymphomas and leukemias, few other tumors metastasized. Nonneoplastlc lesions included cystic hyperplasia of the uterus, nephritis, ovarian and uterine cysts, inflammatory lesions of the lung, mineralization in the brain, and focal hyperplasias in several tissues. The focal hyperplasias in lung and pituitary, adrenal, and thyroid glands were suggestive of the early stages of neoplasia. Comparative aspects of lesions In aging mice and their Interpretation In carcinogenesis tests are discussed.—JNCI 63;. © 1979, Oxford University Press.

引用

页码：849 / 854

页数：6

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