PROTECTION FROM UV-B-INDUCED DNA-DAMAGE BY FLAVONOIDS

被引：147

作者：

KOOTSTRA, A

机构：

[1] BioText International, Auckland, Devonport

来源：

PLANT MOLECULAR BIOLOGY | 1994年 / 26卷 / 02期

关键词：

FLAVONOIDS; UV-B; DNA DAMAGE; IN VITRO TRANSCRIPTION;

D O I：

10.1007/BF00013762

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study an in vitro run-off transcription assay was used to determine if flavonoids can prevent the accumulation of UV-B-induced DNA damage. Template plasmid DNA was irradiated with UV-B light, which resulted in a decreased capacity to support transcription. Purified flavonoids naringenin and rutin as well as flavonoid extracts from apple skin prevented the accumulation of DNA damage. The results support the hypothesis that flavonoids protect DNA from UV-induced DNA damage.

引用

页码：771 / 774

页数：4

共 23 条

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