GLUCOSE-TRANSPORTER PROTEINS IN BRAIN

被引：411
作者：
MAHER, F
VANNUCCI, SJ
SIMPSON, IA
机构：
[1] NIDDKD, BETHESDA, MD 20892 USA
[2] PENN STATE UNIV, MILTON S HERSHEY MED CTR, DEPT PEDIAT, HERSHEY, PA 17033 USA
来源：
FASEB JOURNAL | 1994年 / 8卷 / 13期
关键词：
GLUCOSE TRANSPORT; CEREBRAL GLUCOSE UTILIZATION; NEURONS; GLIA;
D O I：
10.1096/fasebj.8.13.7926364
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glucose is the principal energy source for the mammalian brain. The presence of glucose transport proteins is essential to supply glucose to the neurons and glia within the brain. At least three glucose transporter isoforms have now been identified, and are thought to play a significant role, in the brain. This review describes our current understanding of cell-specific glucose transporter expression in brain, which includes GLUT1 (55-kDa form) present at a high concentration at the blood-brain barrier as well as in parenchymal cells (45-kDa form), most likely in astrocytes, GLUT3 expressed in neurons, and GLUT5 in microglia. We discuss some potential implications of this glucose transporter heterogeneity for cerebral metabolic activity.
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页码：1003 / 1011
页数：9
相关论文
共 65 条
[1]  
APPEL NM, 1992, J PHARMACOL EXP THER, V263, P1415
[2]   CHARACTERIZATION OF GLUT3 PROTEIN EXPRESSED IN CHINESE-HAMSTER OVARY CELLS [J].
ASANO, T ;
KATAGIRI, H ;
TAKATA, K ;
TSUKUDA, K ;
LIN, JL ;
ISHIHARA, H ;
INUKAI, K ;
HIRANO, H ;
YAZAKI, Y ;
OKA, Y .
BIOCHEMICAL JOURNAL, 1992, 288 :189-193
[3]  
BELL GI, 1993, J BIOL CHEM, V268, P19161
[4]   IMMUNOCYTOCHEMICAL DETECTION OF THE MICROSOMAL GLUCOSE-6-PHOSPHATASE IN HUMAN BRAIN ASTROCYTES [J].
BELL, JE ;
HUME, R ;
BUSUTTIL, A ;
BURCHELL, A .
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1993, 19 (05) :429-435
[5]   CHARACTERIZATION OF THE GLUCOSE TRANSPORTER FROM RAT-BRAIN SYNAPTOSOMES [J].
BHATTACHARYYA, MV ;
BRODSKY, JL .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 155 (02) :685-691
[6]   CLONING AND CHARACTERIZATION OF A CDNA-ENCODING THE RAT-BRAIN GLUCOSE-TRANSPORTER PROTEIN [J].
BIRNBAUM, MJ ;
HASPEL, HC ;
ROSEN, OM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (16) :5784-5788
[7]   ONTOGENY AND CELLULAR-DISTRIBUTION OF BRAIN GLUCOSE TRANSPORTER GENE-EXPRESSION [J].
BONDY, CA ;
LEE, WH ;
ZHOU, J .
MOLECULAR AND CELLULAR NEUROSCIENCE, 1992, 3 (04) :305-314
[8]   IMMUNOLOGICAL ANALYSIS OF GLUCOSE TRANSPORTERS EXPRESSED IN DIFFERENT REGIONS OF THE RAT-BRAIN AND CENTRAL-NERVOUS-SYSTEM [J].
BRANT, AM ;
JESS, TJ ;
MILLIGAN, G ;
BROWN, CM ;
GOULD, GW .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 192 (03) :1297-1302
[9]  
BURANT CF, 1992, J BIOL CHEM, V267, P14523
[10]   FACILITATED DIFFUSION OF GLUCOSE [J].
CARRUTHERS, A .
PHYSIOLOGICAL REVIEWS, 1990, 70 (04) :1135-1176
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