CLINICAL-TRIAL DESIGN - VETERINARY PERSPECTIVES

被引：13

作者：

LUND, EM

JAMES, KM

NEATON, JD

机构：

[1] Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota

[2] Division of Biostatistics, School of Public Health, University of Minnesota, St Paul, Minnesota

来源：

JOURNAL OF VETERINARY INTERNAL MEDICINE | 1994年 / 8卷 / 05期

关键词：

D O I：

10.1111/j.1939-1676.1994.tb03243.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Tremendous potential exists for the use of the randomized clinical trial (RCT) in veterinary clinical research. Understanding the fundamentals of RCT design not only benefits clinical researchers, but it can enhance the ability of practitioners to interpret published RCT reports In this article, the essential components of RCT design and implementation are described using examples from clinical veterinary medicine.

引用

页码：317 / 322

页数：6

共 24 条

[1]

Pocock SJ., Clinical Trials. A Practical Approach, (1983)

[2]

Cochran WG., Research techniques in the study of human beings, MilbankQ, 23, pp. 121-136, (1955)

[3]

Hill AB., Observation and experiment, N Engl J Med, 248, pp. 995-1001, (1953)

[4]

Davis CE., The effect of regression to the mean in epidemiologic and clinical studies, Am J Epidemiol, 104, pp. 493-498, (1976)

[5]

Roethlisberger F., Dickson WJ, Wright HA., (1964)

[6]

Smith RD., Veterinary clinical research: A survey of study designs and clinical issues appearing in a practice journal, J Vet Med Educ, 15, pp. 2-7, (1988)

[7]

Hills M., The two‐period cross‐over clinical trial, Br J Clin Pharmacol, 8, pp. 7-20, (1979)

[8]

Meinert C., Clinical Trials. Design, Conduct and Analysis, (1986)

[9]

Armitage P., The role of randomization in clinical trials, Stat Med, 1, pp. 345-352, (1982)

[10]

Zelen M., The randomization and stratification of patients to clinical trials, J Chronic Dis, 27, pp. 365-375, (1974)

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