NEW NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS .2. STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SERIES OF ANNELATED 2(1H)-PYRIDINONES

被引：5

作者：

BANTICK, JR ^{[1
]}

BEATON, HG ^{[1
]}

COOPER, SL ^{[1
]}

HILL, S ^{[1
]}

HIRST, SC ^{[1
]}

MCINALLY, T ^{[1
]}

SPENCER, J ^{[1
]}

TINKER, AC ^{[1
]}

WILLIS, PA ^{[1
]}

机构：

[1] FISONS PLC,DIV PHARMACEUT,R&D LABS,DEPT MED CHEM,LOUGHBOROUGH LE11 0RH,LEICS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(01)81134-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and angiotensin II antagonist activity of biphenyl tetrazole substituted fused bicyclic analogues of 2-pyridinone is described. Potent antagonist activity was found in the 2-quinolinone, thieno[2,3-b] pyridine and imidazo[c]pyridine series.

引用

页码：127 / 132

页数：6

共 13 条

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