EVIDENCE FOR A 3RD TRANSCRIPT FROM THE HUMAN FACTOR-VIII GENE

被引：101
作者：
LEVINSON, B
KENWRICK, S
GAMEL, P
FISHER, K
GITSCHIER, J
机构：
[1] UNIV CALIF SAN FRANCISCO,HOWARD HUGHES MED INST,U-426,BOX 0724,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143
[3] GENENTECH INC,SAN FRANCISCO,CA 94080
来源：
GENOMICS | 1992年 / 14卷 / 03期
关键词：
D O I：
10.1016/S0888-7543(05)80155-7
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Intron 22 of the human factor VIII gene was recently found to contain a gene, associated with a CpG island, which is transcribed in the direction opposite to factor VIII. We now report that another transcript emanates from the island and is transcribed in the same direction as factor VIII. The divergent transcripts originate within 122 bases of each other. The newly identified 5′ exon in intron 22 potentially codes for eight amino acids and is spliced to exons 23-26, with the factor VIII reading frame maintained. The protein encoded by this transcript would include the factor VIII C2 domain, responsible for phospholipid binding and essential for coagulant activity. © 1992 Academic Press, Inc. All rights reserved.
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页码：585 / 589
页数：5
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