CHALCONE TETRAMERS, LOPHIRACHALCONE AND ALATACHALCONE, FROM LOPHIRA-ALATA AS POSSIBLE ANTITUMOR PROMOTERS

被引：26

作者：

MURAKAMI, A

TANAKA, S

OHIGASHI, H

HIROTA, M

IRIE, R

TAKEDA, N

TATEMATSU, A

KOSHIMIZU, K

机构：

[1] KYOTO UNIV, FAC AGR, DEPT FOOD SCI & TECHNOL, KYOTO 606, JAPAN

[2] SHINSHU UNIV, FAC AGR, DEPT BIOSCI & TECHNOL, KAMIINA, NAGANO 39945, JAPAN

[3] MEIJO UNIV, FAC PHARM, TEMPA KU, NAGOYA, AICHI 468, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1992年 / 56卷 / 05期

关键词：

D O I：

10.1271/bbb.56.769

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two chalcone tetramers were isolated as inhibitors of Epstein-Barr virus (EBV)-activation induced by a tumor promoter, teleocidin B-4, from a medicinal plant in tropical west Africa, Lophira alata (Ochnaceae). One of them was identified as lophirachalcone. The other, named alatachalcone, was new, and the structure was determined by spectral properties. Both compounds also showed potent inhibitory activities against teleocidin B-4-induced inflammation on mouse ear. In an initiation-promotion experiment on mouse skin, alatachalcone (16 nmol) significantly inhibited tumor promotion caused by 12-O-tetradecanoyphorbol-13-acetate (TPA, 1.6 nmol).

引用

页码：769 / 772

页数：4

共 20 条

[1]

Berenblum I, 1941, CANCER RES, V1, P807

[2] THE ANTI-INFLAMMATORY ACTIVITY OF GLYCYRRHETINIC ACID AND DERIVATIVES [J].