CCAAT-ENHANCER BINDING-PROTEIN - A COMPONENT OF A DIFFERENTIATION SWITCH

被引：661
|
作者：
UMEK, RM
FRIEDMAN, AD
MCKNIGHT, SL
机构：
[1] Howard Hughes Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210
来源：
SCIENCE | 1991年 / 251卷 / 4991期
关键词：
D O I：
10.1126/science.1987644
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The CCAAT-enhancer binding protein (C/EBP) has now been found to promote the terminal differentiation of adipocytes. During the normal course of adipogenesis, C/EBP expression is restricted to a terminal phase where-in proliferative growth is arrested, and specialized cell phenotype is first manifested. A conditional form of C/EBP was developed, making it feasible to test its capacity to regulate the differentiation of cultured adipocytes. Premature expression of C/EBP in adipoblasts caused a direct cessation of mitotic growth. Moreover, when abetted by the effects of three adipogenic hormones, C/EBP promoted terminal cell differentiation. Since C/EBP is expressed in a variety of tissues, it may have a fundamental role in regulating the balance between cell growth and differentiation in higher animals.
引用
收藏
页码：288 / 292
页数：5
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