CCAAT-ENHANCER BINDING-PROTEIN - A COMPONENT OF A DIFFERENTIATION SWITCH

被引：660
作者：
UMEK, RM
FRIEDMAN, AD
MCKNIGHT, SL
机构：
[1] Howard Hughes Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210
来源：
SCIENCE | 1991年 / 251卷 / 4991期
关键词：
D O I：
10.1126/science.1987644
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The CCAAT-enhancer binding protein (C/EBP) has now been found to promote the terminal differentiation of adipocytes. During the normal course of adipogenesis, C/EBP expression is restricted to a terminal phase where-in proliferative growth is arrested, and specialized cell phenotype is first manifested. A conditional form of C/EBP was developed, making it feasible to test its capacity to regulate the differentiation of cultured adipocytes. Premature expression of C/EBP in adipoblasts caused a direct cessation of mitotic growth. Moreover, when abetted by the effects of three adipogenic hormones, C/EBP promoted terminal cell differentiation. Since C/EBP is expressed in a variety of tissues, it may have a fundamental role in regulating the balance between cell growth and differentiation in higher animals.
引用
收藏
页码：288 / 292
页数：5
相关论文
共 34 条
  • [1] EXPRESSION OF SPECIFIC MESSENGER-RNAS DURING ADIPOSE DIFFERENTIATION - IDENTIFICATION OF AN MESSENGER-RNA ENCODING A HOMOLOG OF MYELIN-P2 PROTEIN
    BERNLOHR, DA
    ANGUS, CW
    LANE, MD
    BOLANOWSKI, MA
    KELLY, TJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (17): : 5468 - 5472
  • [2] TISSUE-SPECIFIC EXPRESSION, DEVELOPMENTAL REGULATION, AND GENETIC-MAPPING OF THE GENE ENCODING CCAAT ENHANCER BINDING-PROTEIN
    BIRKENMEIER, EH
    GWYNN, B
    HOWARD, S
    JERRY, J
    GORDON, JI
    LANDSCHULZ, WH
    MCKNIGHT, SL
    [J]. GENES & DEVELOPMENT, 1989, 3 (08) : 1146 - 1156
  • [3] CAO Z, UNPUB
  • [4] CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
  • [5] DIFFERENTIATION-INDUCED GENE-EXPRESSION IN 3T3-L1 PREADIPOCYTES - CCAAT ENHANCER BINDING-PROTEIN INTERACTS WITH AND ACTIVATES THE PROMOTERS OF 2 ADIPOCYTE-SPECIFIC GENES
    CHRISTY, RJ
    YANG, VW
    NTAMBI, JM
    GEIMAN, DE
    LANDSCHULZ, WH
    FRIEDMAN, AD
    NAKABEPPU, Y
    KELLY, TJ
    LANE, MD
    [J]. GENES & DEVELOPMENT, 1989, 3 (09) : 1323 - 1335
  • [6] THE MYC ONCOGENE - ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION
    COLE, MD
    [J]. ANNUAL REVIEW OF GENETICS, 1986, 20 : 361 - 384
  • [7] MYOD INDUCES GROWTH ARREST INDEPENDENT OF DIFFERENTIATION IN NORMAL AND TRANSFORMED-CELLS
    CRESCENZI, M
    FLEMING, TP
    LASSAR, AB
    WEINTRAUB, H
    AARONSON, SA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (21) : 8442 - 8446
  • [8] EXPRESSION OF A SINGLE TRANSFECTED CDNA CONVERTS FIBROBLASTS TO MYOBLASTS
    DAVIS, RL
    WEINTRAUB, H
    LASSAR, AB
    [J]. CELL, 1987, 51 (06) : 987 - 1000
  • [9] 2 DIFFERENT FACTORS ACT SEPARATELY OR TOGETHER TO SPECIFY FUNCTIONALLY DISTINCT ACTIVITIES AT A SINGLE TRANSCRIPTIONAL ENHANCER
    DEFRANCO, D
    YAMAMOTO, KR
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (04) : 993 - 1001
  • [10] CHIMERAS OF MYC ONCOPROTEIN AND STEROID-RECEPTORS CAUSE HORMONE-DEPENDENT TRANSFORMATION OF CELLS
    EILERS, M
    PICARD, D
    YAMAMOTO, KR
    BISHOP, JM
    [J]. NATURE, 1989, 340 (6228) : 66 - 68
1234