SYNTHESIS OF PROSTAGLANDINS BY SUB-POPULATIONS OF HUMAN PERIPHERAL-BLOOD MONOCYTES

被引：67

作者：

GOLDYNE, ME ^{[1
]}

STOBO, JD ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,MOFFITT HOSP,DEPT MED,RHEUMATOL CLIN IMMUNOL SECT,SAN FRANCISCO,CA 94143

来源：

PROSTAGLANDINS | 1979年 / 18卷 / 05期

关键词：

D O I：

10.1016/0090-6980(79)90089-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of monocytes/macrophages to regulate various aspects of immunologic responses may in part depend on their release of soluble substances such as prostaglandins. Using quantitative gas-liquid chromatography/mass spectrometry, prostaglandin E2 was found to be the major prostaglandin synthesized in culture by human peripheral blood monocytes. Subjecting these cells to discontinuous density gradient fractionation demonstrated significant differences in the synthesis of prostaglandins E2 and E1 among the resulting monocyte subpopulations. © 1979.

引用

页码：687 / 695

页数：9

共 17 条

[1] MASS SPECTROMETRIC DETERMINATION OF PICOMOLE AMOUNTS OF PROSTAGLANDINS-E2 AND F2ALPHA USING SYNTHETIC DEUTERIUM LABELED CARRIERS [J].