SWELLING OF RAT HEPATOCYTES ACTIVATES ACETYL-COA CARBOXYLASE IN PARALLEL TO GLYCOGEN-SYNTHASE

被引：49

作者：

BAQUET, A ^{[1
]}

MAISIN, L ^{[1
]}

HUE, L ^{[1
]}

机构：

[1] CATHOLIC UNIV LOUVAIN,INT INST CELLULAR & MOLEC PATHOL,B-1200 BRUSSELS,BELGIUM

来源：

BIOCHEMICAL JOURNAL | 1991年 / 278卷

关键词：

D O I：

10.1042/bj2780887

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Incubation of hepatocytes in conditions known to increase their volume, i.e. with amino acids or in hypo-osmotic media, resulted in the parallel activation of glycogen synthase and acetyl-CoA carboxylase. The activation of both enzymes by glutamine was antagonized by the addition of raffinose to prevent cell swelling, or by glucagon and microcystin. The findings are consistent with the involvement of a common mechanism for the activation of the two enzymes.

引用

页码：887 / 890

页数：4

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