EPIBATIDINE - A NOVEL (CHLOROPYRIDYL)AZABICYCLOHEPTANE WITH POTENT ANALGESIC ACTIVITY FROM AN ECUADORIAN POISON FROG

被引：549

作者：

SPANDE, TF

GARRAFFO, HM

EDWARDS, MW

YEH, HJC

PANNELL, L

DALY, JW

机构：

[1] NIDDKD,ANALYT CHEM LAB,BETHESDA,MD 20892

[2] NIDDKD,BIOORGAN CHEM LAB,BETHESDA,MD 20892

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1992年 / 114卷 / 09期

关键词：

D O I：

10.1021/ja00035a048

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A potent non-opioid analgesic, epibatidine, has been isolated from skins of the Ecuadoran poison frog, Epipedobates tricolor, and its structure determined by MS, IR, and H-1 NMR analyses as exo-2-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptane. It represents a unique new class of alkaloids.

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页码：3475 / 3478

页数：4

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