A YEAST PROTEIN, HOMOLOGOUS TO THE PROTEOLIPID OF THE CHROMAFFIN GRANULE PROTON-ATPASE, IS IMPORTANT FOR CELL-GROWTH

被引：25
作者：
APPERSON, M
JENSEN, RE
SUDA, K
WITTE, C
YAFFE, MP
机构：
[1] JOHNS HOPKINS UNIV,SCH MED,DEPT CELL BIOL & ANAT,BALTIMORE,MD 21205
[2] UNIV BASEL,BIOCTR,CH-4056 BASEL,SWITZERLAND
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 168卷 / 02期
关键词：
D O I：
10.1016/0006-291X(90)92359-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have characterized a gene, PPA1, adjacent to the yeast MAS2 gene. DNA sequence analysis of PPA1 predicts a hydrophobic protein of 23 kDa. This protein is homologous to the proteolipid of the bovine chromaffin granule proton ATPase and to the proteolipid of the yeast vacuolar proton ATPase. Gene disruption experiments indicate that the PPA1 protein is essential for viability in three unrelated yeast strains and important for optimal growth in a fourth strain. © 1990.
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页码：574 / 579
页数：6
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