CLONING OF THE CDNA AND THE GENOMIC DNA OF THE MOUSE ANGIOTENSIN-II TYPE-2 RECEPTOR

被引：40

作者：

ICHIKI, T ^{[1
]}

HEROLD, CL ^{[1
]}

KAMBAYASHI, Y ^{[1
]}

BARDHAN, S ^{[1
]}

INAGAMI, T ^{[1
]}

机构：

[1] VANDERBILT UNIV,SCH MED,DEPT BIOCHEM,NASHVILLE,TN 37232

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1994年 / 1189卷 / 02期

关键词：

ANGIOTENSIN II; TYPE; 2; RECEPTOR; CDNA; GENOMIC DNA SEQUENCE; (MOUSE);

D O I：

10.1016/0005-2736(94)90072-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Of the two major isoforms of the angiotensin II receptors, type 1 (AT(1)) and type 2 (AT(2)), little is known about the structure and features of AT(2). We cloned a mouse AT(2) cDNA from a mouse fetus cDNA library and an AT(2) genomic DNA from a 129SV mouse genomic DNA library. The amino acid sequence of the mouse AT(2) (363 residues) deduced from a mouse cDNA clone showed seven membrane-spanning domains. Amino acid identity of the mouse AT(2) with mouse AT(1) is 37%, and 98% with rat AT(2). The genomic DNA (4.4 kb) contained three exons and two introns and the entire coding region was contained in the third exon.

引用

页码：247 / 250

页数：4

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