POSTNATAL CHANGES IN RHODAMINE-123 STAINED MITOCHONDRIAL POPULATIONS ARE SENSITIVE TO PROTEIN-SYNTHESIS INHIBITORS BUT MIMICKED IN-VITRO BY ATP

被引：14

作者：

ALMEIDA, A ^{[1
]}

LOPEZMEDIAVILLA, C ^{[1
]}

ORFAO, A ^{[1
]}

MEDINA, JM ^{[1
]}

机构：

[1] UNIV SALAMANCA,FAC FARM,DEPT BIOQUIM & BIOL MOLEC,SERV CITOMETR,E-37007 SALAMANCA,SPAIN

来源：

FEBS LETTERS | 1994年 / 344卷 / 01期

关键词：

MITOCHONDRION; RHODAMINE-123; FLOW CYTOMETRY; POSTNATAL;

D O I：

10.1016/0014-5793(94)00345-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The incubation of term fetus mitochondria with ATP mimicked in vitro the increase in the respiratory control index and in the percentage of the rhodamine-123-low fluorescence population that occurred in vivo immediately after birth, suggesting that both phenomena are closely associated. The administration of streptomycin inhibited the increase in the percentage of the low fluorescence population that occurred immediately after birth, while the administration of cycloheximide even reversed these changes. These results suggest that the in vivo interconversion between mitochondrial forms depends on both cytosolic and mitochondrial protein synthesis.

引用

页码：50 / 54

页数：5

共 25 条

[1] POSTNATAL-DEVELOPMENT OF RAT-LIVER MITOCHONDRIA - STATE-3 RESPIRATION, ADENINE-NUCLEOTIDE TRANSLOCASE ACTIVITY, AND THE NET ACCUMULATION OF ADENINE-NUCLEOTIDES [J].