EXPERIMENTS DIRECTED TOWARDS THE SYNTHESIS OF ANTHRACYCLINONES .23. A SYNTHESIS OF FRIDAMYCIN-E

被引：8

作者：

PAUSLER, MG ^{[1
]}

RUTLEDGE, PS ^{[1
]}

机构：

[1] UNIV AUCKLAND,DEPT CHEM,AUCKLAND,NEW ZEALAND

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1994年 / 47卷 / 12期

关键词：

Anthracyclinones - Enolates - Fridamycin - Menthyl acetate - Solvomercuration;

D O I：

10.1071/CH9942135

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fridamycin E (1) has been synthesized in six steps from the anthrarufin mono(chloroallyl) ether (10). The synthesis was based on a titanium-mediated aldol-like addition of a (-)-menthyl acetate enolate to the ketone (9). Similar additions to the aldehydes (23) and (25) are reported.

引用

页码：2135 / 2147

页数：13

共 6 条

[1] EXPERIMENTS DIRECTED TOWARDS THE SYNTHESIS OF ANTHRACYCLINONES .14. AN INTERMEDIATE FOR THE SYNTHESIS OF VINEOMYCINS
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[3] EXPERIMENTS DIRECTED TOWARDS THE SYNTHESIS OF ANTHRACYCLINONES .16. TIN(IV)-MEDIATED AND TITANIUM(IV)-MEDIATED CYCLIZATIONS OF ORTHO-ALLYL-SUBSTITUTED HOMOCHIRAL HYDROXYANTHRAQUINONE DIOXOLANS
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[5] EXPERIMENTS DIRECTED TOWARDS THE SYNTHESIS OF ANTHRACYCLINONES .24. HOMOCHIRAL INTERMEDIATES FOR VINEOMYCIN SYNTHESES
PAUSLER, MG
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[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1994, 47 (12) : 2149 - 2160
[6] STRUCTURAL, MECHANISTIC, AND THEORETICAL ASPECTS OF CHELATION-CONTROLLED CARBONYL ADDITION-REACTIONS
REETZ, MT
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1993, 26 (09) : 462 - 468

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