MITOMYCIN-C INDUCED ALTERATIONS IN ANTIOXIDANT ENZYME LEVELS IN A MODEL INSECT SPECIES, SPODOPTERA-ERIDANIA

被引:6
作者
BATCABE, JP [1 ]
MACGILL, RS [1 ]
ZAMAN, K [1 ]
AHMAD, S [1 ]
PARDINI, RS [1 ]
机构
[1] UNIV NEVADA, DEPT BIOCHEM 330, NAT PROD LAB, RENO, NV 89557 USA
来源
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1994年 / 25卷 / 03期
关键词
MITOMYCIN C; SPODOPTERA ERIDANIA; SUPEROXIDE DISMUTASE; CATALASE; GLUTATHIONE-S TRANSFERASE; GLUTATHIONE REDUCTASE; DT-DIAPHORASE;
D O I
10.1016/0306-3623(94)90216-X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. An insect species, the southern armyworm Spodoptera eridania, was used as an in vivo model to examine mitomycin C's (MMC) pro-oxidant effect reflected in alterations of antioxidant enzymes. 2. Following a 2-day exposure to 0.01 and 0.05% w/w dietary concentrations, MMC only induced superoxide dismutase activity. All other enzyme activities were not affected, indicating oxidative stress was mild. 3. Following a 5-day exposure to 0.05% w/w dietary MMC, the activities of superoxide dismutase, glutathione-S-transferase and its peroxidase activity and DT-diaphorase were induced. GR activity was not altered. The high constitutive catalase activity was also not affected. These responses of S. eridania's antioxidant enzymes are analogous to those of mammalian systems in alleviating MMC-induced oxidative stress. 4. S. eridania emerges as an appropriate non-mammalian model for initial and cost-effective screening of drug-induced oxidative stress.
引用
收藏
页码:569 / 574
页数:6
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