VIRULENT TREPONEMA-PALLIDUM PROMOTES ADHESION OF LEUKOCYTES TO HUMAN VASCULAR ENDOTHELIAL-CELLS

被引:28
作者
RILEY, BS
OPPENHEIMERMARKS, N
RADOLF, JD
NORGARD, MV
机构
[1] UNIV TEXAS,SW MED CTR,DEPT MICROBIOL,DALLAS,TX 75235
[2] UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED,DALLAS,TX 75235
关键词
D O I
10.1128/IAI.62.10.4622-4625.1994
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Perivasculitis and endothelial cell abnormalities are characteristic histopathologic features of syphilis, a sexually transmitted disease caused by Treponema pallidum. To extend earlier studies demonstrating the T. pallidum activates endothelial cells, we now show that virulent T. pallidum, but not heat-killed T. pallidum or nonpathogenic Treponema phagedenis, promotes increased adherence of lymphocytes and monocytes to human umbilical vein endothelial cells, Lymphocytes and monocytes are the two cell types prominent in the histopathology of syphilis. Recognition that T. pallidum can stimulate endothelial cells to bind leukocytes provides important insights into the early mechanisms of syphilis immunopathogenesis.
引用
收藏
页码:4622 / 4625
页数:4
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