PROTON NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY OF URINE AND PLASMA IN RENAL-TRANSPLANTATION FOLLOW-UP

被引：64
作者：
LEMOYEC, L
PRUNA, A
EUGENE, M
BEDROSSIAN, J
IDATTE, JM
HUNEAU, JF
TOME, D
机构：
[1] HOP ST LOUIS,SERV NEPHROL,F-75010 PARIS,FRANCE
[2] FAC PHARM PARIS,INRA,NUTR HUMAINE LAB,F-75270 PARIS 06,FRANCE
来源：
NEPHRON | 1993年 / 65卷 / 03期
关键词：
PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RENAL TRANSPLANTATION; URINE; PLASMA;
D O I：
10.1159/000187525
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Urine and plasma samples from 39 patients who underwent renal transplantation were analyzed by proton nuclear magnetic resonance (NMR) spectroscopy. The most relevant resonances for evaluating renal function after transplantation were those arising from citrate, trimethylamine-N-oxide (TMAO), alanine, and lactate when compared to creatinine. A resonance at 3.7 ppm was related to cyclosporine toxicity when associated with elevated levels of TMAO. The respective variations in these metabolites in urine could contribute to prognosis and diagnosis of renal function impairment related to cyclosporine toxicity or overdosage, or to rejection. Thus, NMR spectroscopy should improve the follow-up and management of renal transplantation patients.
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页码：433 / 439
页数：7
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