EFFECT OF PROPOFOL ON MEMORY IN MICE

被引:30
作者
PANG, R
QUARTERMAIN, D
ROSMAN, E
TURNDORF, H
机构
[1] NYU,SCH MED,DEPT ANESTHESIOL,NEW YORK,NY 10016
[2] NYU,SCH MED,DEPT NEUROL,NEW YORK,NY 10016
关键词
PROPOFOL; ANESTHESIA; MEMORY; ANTEROGRADE AMNESIA; PASSIVE AVOIDANCE LEARNING;
D O I
10.1016/0091-3057(93)90292-2
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The amnestic effects of the intravenous hypnotic anesthetic agent 2,6-diisopropylphenol (propofol; Diprivan) were studied in a single-trial passive avoidance task. Mice were injected with propofol 10 min before or immediately after training. Memory was impaired in a dose-dependent fashion when the anesthetic was administered before learning, but no amnesia was apparent with posttraining injections. Examination of the acquisition of passive avoidance using a multitrial task showed that propofol-treated mice learned the response normally but forgot the learning significantly faster than vehicle-treated controls. The anterograde amnesia was not the result of state-dependent learning. Propofol also disrupted ''tinction of fear conditioning when the anesthetic was given during the extinction session. Propofol-induced amnesia could be attenuated by amphetamine (1 mg/kg) injected 30 min before the retention test.
引用
收藏
页码:145 / 151
页数:7
相关论文
共 19 条
[1]  
BENNETT HL, 1986, ANESTH ANALG, V65, P988
[2]  
BONKE B, 1990, MEMORY AWARENESS ANA
[3]  
DUBOVSKY SL, 1976, ANESTH ANALG, V55, P696
[4]  
GOLDMANN L, 1990, MEMORY AWARENESS ANA, P45
[5]  
GOLDMANN L, 1987, CONSCIOUSNESS AWAREN, P140
[6]   EEG INVESTIGATION OF AWARENESS DURING ANESTHESIA [J].
LEWIS, SA ;
JENKINSON, J ;
WILSON, J .
BRITISH JOURNAL OF PSYCHOLOGY, 1973, 64 (AUG) :413-415
[7]   CENTRAL AND PERIPHERAL ACTIONS OF AMPHETAMINE ON MEMORY STORAGE [J].
MARTINEZ, JL ;
JENSEN, RA ;
MESSING, RB ;
VASQUEZ, BJ ;
SOUMIREUMOURAT, B ;
GEDDES, D ;
LIANG, KC ;
MCGAUGH, JL .
BRAIN RESEARCH, 1980, 182 (01) :157-166
[8]  
NOBLE J, 1985, POSTGRAD MED J, V61, P103
[9]   BIOCHEMICAL AND ELECTROPHYSIOLOGIC EVIDENCE THAT PROPOFOL ENHANCES GABAERGIC TRANSMISSION IN THE RAT-BRAIN [J].
PEDUTO, VA ;
CONCAS, A ;
SANTORO, G ;
BIGGIO, G ;
GESSA, GL .
ANESTHESIOLOGY, 1991, 75 (06) :1000-1009
[10]   STRENGTH OF SCOPOLAMINE-INDUCED AMNESIA AS A FUNCTION OF TIME BETWEEN TRAINING AND TESTING [J].
QUARTERMAIN, D ;
LEO, P .
BEHAVIORAL AND NEURAL BIOLOGY, 1988, 50 (03) :300-310