MOLECULAR-CLONING AND BINDING-PROPERTIES OF THE HUMAN TYPE-II ACTIVIN RECEPTOR

被引：83
作者：
DONALDSON, CJ
MATHEWS, LS
VALE, WW
机构：
[1] Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 184卷 / 01期
关键词：
D O I：
10.1016/0006-291X(92)91194-U
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A full-length cDNA for the type II human activin receptor was cloned by hybridization from a human testis cDNA library. The sequence encodes a 513 amino acid protein that is 99% identical, at the amino acid level, with the mouse type II activin receptor. The type II human activin receptor consists of an extracellular domain that specifically binds activin A with a Kd of 360 pM, a single-membrane spanning domain, and an intracellular kinase domain with predicted serine/threonine specificity. © 1992.
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页码：310 / 316
页数：7
相关论文
共 32 条
[11]   DUAL EFFECT OF ACTIVIN-A ON CELL-GROWTH IN BALB/C-3T3-CELLS [J].
KOJIMA, I ;
OGATA, E .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 159 (03) :1107-1113
[12]   IDENTIFICATION OF THE 2 TYPES OF SPECIFIC RECEPTOR FOR ACTIVIN/EDF EXPRESSED ON FRIEND-LEUKEMIA AND EMBRYONAL CARCINOMA-CELLS [J].
KONDO, S ;
HASHIMOTO, M ;
ETOH, Y ;
MURATA, M ;
SHIBAI, H ;
MURAMATSU, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 161 (03) :1267-1272
[13]   ACTIVIN STIMULATION OF INHIBIN SECRETION AND MESSENGER-RNA LEVELS IN CULTURED GRANULOSA-CELLS [J].
LAPOLT, PS ;
SOTO, D ;
SU, JG ;
CAMPEN, CA ;
VAUGHAN, J ;
VALE, W ;
HSUEH, AJW .
MOLECULAR ENDOCRINOLOGY, 1989, 3 (10) :1666-1673
[14]   PITUITARY FSH IS RELEASED BY A HETERODIMER OF THE BETA-SUBUNITS FROM THE 2 FORMS OF INHIBIN [J].
LING, N ;
YING, SY ;
UENO, N ;
SHIMASAKI, S ;
ESCH, F ;
HOTTA, M ;
GUILLEMIN, R .
NATURE, 1986, 321 (6072) :779-782
[15]   STRUCTURE OF 2 HUMAN OVARIAN INHIBINS [J].
MASON, AJ ;
NIALL, HD ;
SEEBURG, PH .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 135 (03) :957-964
[16]  
MASSAGUE J, 1990, ANN NY ACAD SCI, V593, P59
[17]   EXPRESSION CLONING OF AN ACTIVIN RECEPTOR, A PREDICTED TRANSMEMBRANE SERINE KINASE [J].
MATHEWS, LS ;
VALE, WW .
CELL, 1991, 65 (06) :973-982
[18]  
MATHEWS LS, 1991, P ENDOCRINE SOC, V73, P1516
[19]  
MATHEWS LS, 1992, IN PRESS SCIENCE
[20]   LIGAND - A VERSATILE COMPUTERIZED APPROACH FOR CHARACTERIZATION OF LIGAND-BINDING SYSTEMS [J].
MUNSON, PJ ;
RODBARD, D .
ANALYTICAL BIOCHEMISTRY, 1980, 107 (01) :220-239
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