MOLECULAR-CLONING AND BINDING-PROPERTIES OF THE HUMAN TYPE-II ACTIVIN RECEPTOR

被引：83
作者：
DONALDSON, CJ
MATHEWS, LS
VALE, WW
机构：
[1] Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 184卷 / 01期
关键词：
D O I：
10.1016/0006-291X(92)91194-U
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A full-length cDNA for the type II human activin receptor was cloned by hybridization from a human testis cDNA library. The sequence encodes a 513 amino acid protein that is 99% identical, at the amino acid level, with the mouse type II activin receptor. The type II human activin receptor consists of an extracellular domain that specifically binds activin A with a Kd of 360 pM, a single-membrane spanning domain, and an intracellular kinase domain with predicted serine/threonine specificity. © 1992.
引用
收藏
页码：310 / 316
页数：7
相关论文
共 32 条
[1]   NOVEL ACTIVIN RECEPTORS - DISTINCT GENES AND ALTERNATIVE MESSENGER-RNA SPLICING GENERATE A REPERTOIRE OF SERINE THREONINE KINASE RECEPTORS [J].
ATTISANO, L ;
WRANA, JL ;
CHEIFETZ, S ;
MASSAGUE, J .
CELL, 1992, 68 (01) :97-108
[2]   CHARACTERIZATION OF ACTIVIN-A BINDING-SITES ON THE HUMAN-LEUKEMIA CELL-LINE K562 [J].
CAMPEN, CA ;
VALE, W .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 157 (02) :844-849
[3]   ACTIVIN-A BINDING AND BIOCHEMICAL EFFECTS IN OSTEOBLAST-ENRICHED CULTURES FROM FETAL-RAT PARIETAL BONE [J].
CENTRELLA, M ;
MCCARTHY, TL ;
CANALIS, E .
MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (01) :250-258
[4]   PURIFICATION AND CHARACTERIZATION OF ERYTHROID-DIFFERENTIATION FACTOR (EDF) ISOLATED FROM HUMAN-LEUKEMIA CELL-LINE THP-1 [J].
ETO, Y ;
TSUJI, T ;
TAKEZAWA, M ;
TAKANO, S ;
YOKOGAWA, Y ;
SHIBAI, H .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 142 (03) :1095-1103
[5]   CLONING AND SEQUENCE-ANALYSIS OF CDNA SPECIES CODING FOR THE 2 SUBUNITS OF INHIBIN FROM BOVINE FOLLICULAR-FLUID [J].
FORAGE, RG ;
RING, JM ;
BROWN, RW ;
MCINERNEY, BV ;
COBON, GS ;
GREGSON, RP ;
ROBERTSON, DM ;
MORGAN, FJ ;
HEARN, MTW ;
FINDLAY, JK ;
WETTENHALL, REH ;
BURGER, HG ;
DEKRETSER, DM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (10) :3091-3095
[6]   ACTIVIN-A, INHIBIN AND TRANSFORMING GROWTH FACTOR-BETA MODULATE GROWTH OF 2 GONADAL CELL-LINES [J].
GONZALEZMANCHON, C ;
VALE, W .
ENDOCRINOLOGY, 1989, 125 (03) :1666-1672
[7]  
GREEN JBA, 1990, NATURE, V347, P391, DOI 10.1038/347391a0
[8]   ACTIVIN EDF AS AN INHIBITOR OF NEURAL DIFFERENTIATION [J].
HASHIMOTO, M ;
KONDO, S ;
SAKURAI, T ;
ETOH, Y ;
SHIBAI, H ;
MURAMATSU, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 173 (01) :193-200
[9]   INHIBIN AND ACTIVIN REGULATE [H-3]THYMIDINE UPTAKE BY RAT THYMOCYTES AND 3T3 CELLS-INVITRO [J].
HEDGER, MP ;
DRUMMOND, AE ;
ROBERTSON, DM ;
RISBRIDGER, GP ;
DEKRETSER, DM .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1989, 61 (01) :133-138
[10]  
HINO M, 1989, J BIOL CHEM, V264, P10309
1234