TERATOGENIC EFFECTS OF N-NITROSODIETHYLAMINE IN EMBRYOS OF THE HERMAPHRODITIC FISH RIVULUS-MARMORATUS

被引：11

作者：

PARK, EH

KIM, DS

CHANG, HH

机构：

[1] Department of Biology, College of Natural Sciences, Hanyang University, Seoul

[2] Department of Aquaculture, National Fisheries, University of Pusan, Pusan

来源：

TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS | 1992年 / 12卷 / 03期

关键词：

N-NITROSODIETHYLAMINE; TERATOGENICITY; HERMAPHRODITIC FISH; EMBRYOS; ORGANOGENESIS;

D O I：

10.1002/tcm.1770120304

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Exposure of N-nitrosodiethylamine (NDEA) to hermaphroditic fish (Rivulus marmoratus) embryos induced specific congenital malformations when the chemical was applied to embryos on days 0-6 post morula stage. This sensitive period generally coincided with the known period of organogenesis in this species, and the incidence of anomalies was clearly dose related. These results indicate that NDEA is teratogenic to fish embryos.

引用

页码：129 / 133

页数：5

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