DUAL-ACTION PENEMS AND CARBAPENEMS

被引：42

作者：

CORRAZ, AJ ^{[1
]}

DAX, SL ^{[1
]}

DUNLAP, NK ^{[1
]}

GEORGOPAPADAKOU, NH ^{[1
]}

KEITH, DD ^{[1
]}

PRUESS, DL ^{[1
]}

ROSSMAN, PL ^{[1
]}

THEN, R ^{[1
]}

UNOWSKY, J ^{[1
]}

WEI, CC ^{[1
]}

机构：

[1] HOFFMANN LA ROCHE INC,ROCHE RES CTR,NUTLEY,NJ 07110

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 35卷 / 10期

关键词：

D O I：

10.1021/jm00088a019

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new series of dual-action antibacterial agents were synthesized in which penems and carbapenems were linked at the 2'-position to quinolones through either an ester or a carbamate moiety. Potent, broad-spectrum antibacterial activity was observed for both classes of compounds, indicative of a dual-mode of action.

引用

页码：1828 / 1839

页数：12

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