INVOLVEMENT OF ADHESION MOLECULES (CD11A-ICAM-1) IN VASCULAR ENDOTHELIAL-CELL INJURY ELICITED BY PMA-STIMULATED NEUTROPHILS

被引：25

作者：

FUJITA, H ^{[1
]}

MORITA, I ^{[1
]}

MUROTA, S ^{[1
]}

机构：

[1] KYORIN UNIV,SCH MED,DEPT INTERNAL MED 2,MITAKA,TOKYO 181,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 177卷 / 02期

关键词：

D O I：

10.1016/0006-291X(91)91840-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protective effect of anti-CD11a and anti-ICAM-1 antibodies on the cytotoxicity induced by PMA-stimulated neutrophils was studied using cultured endothelial cells isolated from bovine carotid artery. Anti-CD11a antibody and anti-ICAM-1 antibody inhibited the endothelial cell injury induced by the activated neutrophils in a dose dependent manner. On the other hand, both antibodies themselves had no effect on either the luminol chemiluminescence released out of the activated neutrophils or the adhesion of the neutrophils to the endothelial cell monolayer. These data suggest that these adhesion molecules play some important roles in the vascular endothelial cell injury elicited by activated neutrophils. © 1991.

引用

页码：664 / 672

页数：9

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