REGULATION OF ACETYLCHOLINE SYNTHESIS - CONTROL OF CHOLINE TRANSPORT AND ACETYLATION IN SYNAPTOSOMES

被引：33

作者：

JOPE, RS ^{[1
]}

WEILER, MH ^{[1
]}

JENDEN, DJ ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,INST BRAIN RES,LOS ANGELES,CA 90024

来源：

JOURNAL OF NEUROCHEMISTRY | 1978年 / 30卷 / 05期

关键词：

D O I：

10.1111/j.1471-4159.1978.tb12386.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— The high affinity transport of choline (Ch) and the synthesis of acetylcholine (ACh) were measured in synaptosomes by measuring the utilization of [2H4]Ch. The synthesis of ACh was reduced under several conditions which reduce the availability of acetyl coenzyme A (AcCoA) including no glucose added, replacement of glucose with succinate or impairment of glucose utilization by bromopyr‐uvate, NaCN, or pentobarbital. These conditions did not reduce the amount of unacetylated [2H4]Ch in the synaptosomes indicating that the high affinity transport of Ch is not directly coupled to the synthesis of ACh. Copyright © 1978, Wiley Blackwell. All rights reserved

引用

页码：949 / 954

页数：6

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