Design and Optimization of Rivaroxaban Lipid Solid Dispersion for Dissolution Enhancement using Statistical Experimental Design

被引：0
作者：
Ganesh, M. [1 ]
Shekar, B. Chandra [2 ]
Madhusudan, Y. [3 ]
机构：
[1] Jawaharlal Nehru Technol Univ, Dept Pharmaceut Sci, Hyderabad, Telangana, India
[2] Bomma Inst Pharm, Dept Pharmaceut, Khammam, Telangana, India
[3] Vagdevi Coll Pharm, Dept Pharmaceut, Warangal, Telangana, India
来源：
ASIAN JOURNAL OF PHARMACEUTICS | 2016年 / 10卷 / 01期
关键词：
Box-Behnken design; compitrol HD5 ATO Labrasol; dissolution; Gelucire; 48/16; Rivaroxaban; lipid solid dispersion;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: The purpose of the present study was to understand the effect of formulation variables of lipid solid dispersion on the dissolution of a model drug, rivaroxaban. Method: A three-factor, three-level Box-Behnken design was used to explore the main and interaction effect of several independent formulation variables including the amount of Gelucire 48/16 (X-1), Compitrol HD5 ATO (X-2), and Labrasol (X-3). Particle size (Y-1) and dissolution percentage of rivaroxaban (Y-2) were the dependent variables. Statistical Analysis: A mathematical relationship was obtained to explain the effect of all factors and their colinearities on the dissolution of rivaroxaban. Results: A formulation optimization was then performed to maximize dissolution percentage of rivaroxaban (Y-2). The optimized formulation was predicted to dissolution 62.4% of rivaroxaban at 5 min, when X-1, X-2, and X-3 values were 20.0, 30.0, and 2.0 mg, respectively. Conclusion: In conclusion, the Box-Behnken experimental design allowed us to understand the effect of formulation variables on the dissolution of rivaroxaban from lipid solid dispersion, and optimize the formulation to obtain drug dissolution.
引用
收藏
页码：59 / 64
页数：6
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