IMMUNOLOGICAL FINDINGS IN PATIENTS WITH MYELODYSPLASTIC SYNDROME

被引:9
作者
FELZMANN, T
GISSLINGER, H
LUDWIG, H
机构
[1] Medical Department, Wilheminenspital, Vienna
[2] Cellular Immunology Section, Metabolism Branch, National Cancer Institute, NIH, Bethesda, MD
[3] Internal Medicine I., University Vienna, Vienna
关键词
MYELODYSPLASTIC SYNDROMES; IMMUNOPHENOTYPING; FLOW CYTOMETRY; CYTOKINES;
D O I
10.3109/10428199409049716
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Activation of monocytes and granulocytes in vitro by cytokines, in vivo administration of cytokines, as well as in vivo cytokine production due to infectious and inflammatory diseases causes changes of the surface expression density of certain membrane molecules. In recent studies we attempted to determine the feasibility of using flow cytometric immunophenotyping as a tool to develop a sensitive parameter for detecting infections at an early stage of disease when clinical parameters are still negative. Since infections are an important factor determining the clinical course of myelodysplastic syndromes (MDS), early detection of infection might be beneficial for these immunocompromised patients. We indeed found activation-associated immunophenotypic changes of cell surface antigens on monocytes and granulocytes of clinically infection free MDS patients suggesting enhanced immune activity in these patients, most likely due to latent or beginning infections. In particular, analyses of the expression density of receptors for IgG (Fc gamma Rs), complement receptors, and certain activation-associated surface molecules such as the CD67 and the M5 molecule seem to be of clinical relevance. We will also discuss findings concerning changes of cytokine levels and functional alterations of immunologic parameters in MDS patients.
引用
收藏
页码:201 / 208
页数:8
相关论文
共 51 条
  • [1] Guyre P.M., Campbell A.S., Kniffin W.D., Fanger M.W., Monocytes and Polymorphonuclear Neutrophils of Patients with Streptococcal Pharyngitis Express Increased Numbers of Type I IgG Fc Receptors, J. Clin. Invest., 86, pp. 1892-1896, (1990)
  • [2] Felzmann T., Gadd S., Majdic O., Maurer D., Petera P., Smolen J., Knapp W., Analysis of function-associated receptor molecules on peripheral blood and synovial fluid granulocytes from patients with rheumatoid and reactive arthritis, J. Clin. Immunol., 11, pp. 205-212, (1991)
  • [3] Gadd S.J., Felzmann T., Majdic O., Maurer D., Petera P., Smolen J., Knapp W., Phenotypic analysis of functionally associated molecules on peripheral blood and synovial fluid monocytes from arthritis patients, Rheumatol. Int., 12, pp. 153-157, (1992)
  • [4] Weisdorf D.J., Oken M.M., Johnson G.J., Rydell R.E., Chronic myelodysplastic syndrome: short survival with our without evolution to acute leukemia, Br. J. Haematol., 55, pp. 691-700, (1983)
  • [5] Koeffler H.P., Myelodysplastic syndromes (preleukemia), Semin. Hematol., 23, pp. 284-299, (1986)
  • [6] Bennet J.M., Catovsky D., Daniel M.T., Flandrin G., Galton D.A.G., Gralnick H.R., Sultan C., The French-American-British (FAB) Cooperative Group. Proposal for the classification of the myelodysplastic syndromes, Br. J. Haematol., 51, pp. 189-199, (1982)
  • [7] Mufti G.F., Stevens J.R., Oscier D.G., Hamblin T.J., Machin D., Myelodysplastic syndromes: a scoring system with prognostic significance, Br. J. Haematol., 59, pp. 425-433, (1985)
  • [8] Esparza I., Fox R.I., Schreiber R.D., Interferon-g-dependent modulation of C3b receptors (CR1) on human peripheral blood monocytes, J. Immunol., 136, pp. 1360-1365, (1986)
  • [9] Petroni K.C., Shen L., Guyre P.M., Modulation of human polymorphonuclear leucocyte IgG Fc receptors and Fc receptor mediated functions by IFN-g and glucocorticoids, J. Immunol., 140, pp. 3467-3472, (1988)
  • [10] Shen L., Guyre P.M., Fanger M.W., Polymorphonuclear leucocyte function triggered through the high affinity Fc receptor for monomelic IgG, J. Immunol., 139, pp. 534-538, (1987)