LYSERGIC-ACID DIETHYLAMIDE IS A PARTIAL AGONIST AT 5-HT2 RECEPTORS IN OVINE UTERINE ARTERY OF LATE PREGNANCY

被引：5

作者：

ZHANG, LB ^{[1
]}

DYER, DC ^{[1
]}

机构：

[1] IOWA STATE UNIV SCI & TECHNOL,COLL VET MED,DEPT VET PHYSIOL & PHARMACOL,AMES,IA 50011

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 230卷 / 01期

关键词：

LSD (D-LYSERGIC ACID DIETHYLAMIDE); 5-HT RECEPTORS; DISSOCIATION CONSTANT; UTERINE ARTERY (SHEEP);

D O I：

10.1016/0014-2999(93)90420-M

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

d-Lysergic acid diethylamide (LSD) produced dose-dependent contractions (EC50, 17.9 +/- 2.1 nM) on isolated ovine uterine artery of late pregnancy, which were competitively antagonized by ketanserin. The maximal contraction to LSD was 51% of the 5-HT response. LSD competitively antagonized (pA2 9.21) contractions produced to 5-hydroxytryptamine (5-HT). The results indicate that LSD is a partial agonist at 5-HT2 receptors in ovine uterine artery.

引用

页码：115 / 117

页数：3

共 10 条

[1] SOME QUANTITATIVE USES OF DRUG ANTAGONISTS [J].

ARUNLAKSHANA, O ;

SCHILD, HO .

BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1959, 14 (01) :48-58

[2] COMPARATIVE ACTIONS OF SELECTED VASOACTIVE DRUGS ON ISOLATED HUMAN UTERINE ARTERIES [J].

DYER, DC ;

GOUGH, ED .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1971, 111 (06) :820-&

[3]

DYER DC, 1983, PHARMACOLOGIST, V25, P137

[4] D-LYSERGIC ACID DIETHYLAMIDE (LSD-25) - CONSTRICTOR OF HUMAN UMBILICAL VEIN [J].

GANT, DW ;

DYER, DC .

LIFE SCIENCE PART 1 PHYSIOLOGY & PHARMACOLOGY, 1971, 10 (04) :235-&

[5] CHARACTERIZATION OF [H-3]-LABELED LYSERGIC-ACID DIETHYLAMIDE BINDING TO A 5-HYDROXYTRYPTAMINE RECEPTOR ON HUMAN-PLATELET MEMBRANES [J].

GEANEY, DP ;

SCHACHTER, M ;

ELLIOT, JM ;

GRAHAMESMITH, DG .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 97 (1-2) :87-93

[6]

PEROUTKA SJ, 1986, J NEUROCHEM, V47, P529

[7]

PEROUTKA SJ, 1979, MOL PHARMACOL, V16, P687

[8]

PIERCE PA, 1988, J PHARMACOL EXP THER, V247, P918

[9]

SANDERSBUSH E, 1988, J PHARMACOL EXP THER, V246, P924

[10]

ZHANG L, 1990, J PHARMACOL EXP THER, V253, P1236

← 1 →