ENZYME ASSISTED PREPARATION OF ENANTIOMERICALLY PURE BETA-ADRENERGIC BLOCKERS .3. OPTICALLY-ACTIVE CHLOROHYDRIN DERIVATIVES AND THEIR CONVERSION

被引：45

作者：

ADER, U ^{[1
]}

SCHNEIDER, MP ^{[1
]}

机构：

[1] BERG UNIV GESAMTHSCH WUPPERTAL,FACHBEREICH 9,W-5600 WUPPERTAL 1,GERMANY

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0957-4166(00)80256-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Optical active chlorohydrin derivatives 2a-m and 3a-m of both enantiomeric series were prepared via both enzymatic hydrolyses and acyltransfer reactions catalysed by a highly selective lipase from Pseudomonas sp.. The resulting building blocks were further transformed into the corresponding beta-blockers of high enantiomeric purity.

引用

页码：521 / 524

页数：4

共 34 条

[1] ENZYME ASSISTED PREPARATION OF ENANTIOMERICALLY PURE BETA-ADRENERGIC BLOCKERS .2. BUILDING-BLOCKS OF HIGH OPTICAL PURITY AND THEIR SYNTHETIC CONVERSION [J].

ADER, U ;

SCHNEIDER, MP .

TETRAHEDRON-ASYMMETRY, 1992, 3 (02) :205-208

[2] ENZYME ASSISTED PREPARATION OF ENANTIOMERICALLY PURE BETA-ADRENERGIC BLOCKERS .1. A FACILE SCREENING METHOD FOR SUITABLE BIOCATALYSTS [J].

ADER, U ;

SCHNEIDER, MP .

TETRAHEDRON-ASYMMETRY, 1992, 3 (02) :201-204

[3]

BARRET AM, 1974, Patent No. 3836671

[4] PRACTICAL CHEMOENZYMATIC SYNTHESIS OF BOTH ENANTIOMERS OF PROPRANOLOL [J].

BEVINAKATTI, HS ;

BANERJI, AA .

JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (18) :5372-5375

[5]

BRANDSTROM A, 1966, ACTA PHARM SUEC, V3, P303

[6] QUANTITATIVE-ANALYSES OF BIOCHEMICAL KINETIC RESOLUTIONS OF ENANTIOMERS [J].

CHEN, CS ;

FUJIMOTO, Y ;

GIRDAUKAS, G ;

SIH, CJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (25) :7294-7299

[7] NUCLEAR MAGNETIC-RESONANCE ENANTIOMER REAGENTS - CONFIGURATIONAL CORRELATIONS VIA NUCLEAR MAGNETIC-RESONANCE CHEMICAL-SHIFTS OF DIASTEREOMERIC MANDELATE, O-METHYLMANDELATE, AND ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETATE (MTPA) ESTERS [J].

DALE, JA ;

MOSHER, HS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (02) :512-519

[8] ABSOLUTE CONFIGURATION BY ASYMMETRIC SYNTHESIS OF (+)-1-(4-ACETAMIDOPHENOXY)-3-(ISOPROPYLAMINO)-PROPAN-2-OL (PRACTOLOL) [J].

DANILEWICZ, JC ;

KEMP, JEG .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (02) :168-169

[9] LIPASE-CATALYZED STEREOSELECTIVE HYDROLYSIS OF DIOL DERIVATIVES .1. LIPASE-CATALYZED STEREOSELECTIVE HYDROLYSIS OF 2-ACYLOXY-3-CHLOROPROPYL PARA-TOLUENESULFONATE [J].

HAMAGUCHI, S ;

OHASHI, T ;

WATANABE, K .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1986, 50 (02) :375-380

[10] OPTICAL ISOMERS OF PROPRANOLOL [J].

HOWE, R ;

SHANKS, RG .

NATURE, 1966, 210 (5043) :1336-+

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