SURAMIN INHIBITS INVITRO INFECTION BY DUCK HEPATITIS-B VIRUS, ROUS-SARCOMA VIRUS, AND HEPATITIS-DELTA VIRUS

被引：55

作者：

PETCU, DJ ^{[1
]}

ALDRICH, CE ^{[1
]}

COATES, L ^{[1
]}

TAYLOR, JM ^{[1
]}

MASON, WS ^{[1
]}

机构：

[1] FOX CHASE CANC CTR, INST CANC RES, 7701 BURHOLME AVE, PHILADELPHIA, PA 19111 USA

来源：

VIROLOGY | 1988年 / 167卷 / 02期

关键词：

D O I：

10.1016/S0042-6822(88)90099-2

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Suramin blocked in vitro infection by duck hepatitis B virus, a hepadnavirus, and Rous sarcoma virus, a retrovirus. Although suramin was able to inhibit the virus-encoded reverse transcriptase activities of these two viruses, this inhibition did not appear to account for the anti-viral effect of the drug. In particular, suramin was unable to block synthesis within cells of full-length viral DNAs when added subsequent to infection. The results are consistent with the hypothesis that suramin acted by blocking virus uptake or uncoating. As further support of this hypothesis, we found that suramin also blocked infection by hepatitis delta virus, an RNA virus that is not known to employ reverse transcriptase during the initiation of infection.

引用

页码：385 / 392

页数：8

共 36 条

[1] STRUCTURE AND REPLICATION OF THE GENOME OF THE HEPATITIS DELTA-VIRUS [J].

CHEN, PJ ;

KALPANA, G ;

GOLDBERG, J ;

MASON, W ;

WERNER, B ;

GERIN, J ;

TAYLOR, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (22) :8774-8778

[2] SURAMIN THERAPY IN AIDS AND RELATED DISORDERS - REPORT OF THE UNITED-STATES-SURAMIN-WORKING-GROUP [J].

CHESON, BD ;

LEVINE, AM ;

MILDVAN, D ;

KAPLAN, LD ;

WOLFE, P ;

RIOS, A ;

GROOPMAN, JE ;

GILL, P ;

VOLBERDING, PA ;

POIESZ, BJ ;

GOTTLIEB, MS ;

HOLDEN, H ;

VOLSKY, DJ ;

SILVER, SS ;

HAWKINS, MJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1987, 258 (10) :1347-1351

[3] SURAMIN - POTENT INHIBITOR OF THE REVERSE-TRANSCRIPTASE OF RNA TUMOR-VIRUSES [J].

DECLERCQ, E .

CANCER LETTERS, 1979, 8 (01) :9-22

[4] MOLECULAR-CLONING AND CHARACTERIZATION OF AVIAN-SARCOMA VIRUS CIRCULAR DNA-MOLECULES [J].

DELORBE, WJ ;

LUCIW, PA ;

GOODMAN, HM ;

VARMUS, HE ;

BISHOP, JM .

JOURNAL OF VIROLOGY, 1980, 36 (01) :50-61

[5]

Hawking F, 1978, Adv Pharmacol Chemother, V15, P289, DOI 10.1016/S1054-3589(08)60486-X

[6] SINGLE-STRANDED REGIONS ON UNINTEGRATED AVIAN RETROVIRUS DNA [J].

HSU, TW ;

TAYLOR, JM .

JOURNAL OF VIROLOGY, 1982, 44 (01) :47-53

[7] INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-I REVERSE-TRANSCRIPTASE BY SURAMIN-RELATED COMPOUNDS [J].

JENTSCH, KD ;

HUNSMANN, G ;

HARTMANN, H ;

NICKEL, P .

JOURNAL OF GENERAL VIROLOGY, 1987, 68 :2183-2192

[8] LACK OF RESPONSE TO SURAMIN IN PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX [J].

KAPLAN, LD ;

WOLFE, PR ;

VOLBERDING, PA ;

FEORINO, P ;

LEVY, JA ;

ABRAMS, DI ;

KIPROV, D ;

WONG, R ;

KAUFMAN, L ;

GOTTLIEB, MS .

AMERICAN JOURNAL OF MEDICINE, 1987, 82 (03) :615-620

[9] SURAMIN ANTIVIRAL THERAPY IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME - CLINICAL, IMMUNOLOGICAL, AND VIROLOGICAL RESULTS [J].

LEVINE, AM ;

GILL, PS ;

COHEN, J ;

HAWKINS, JG ;

FORMENTI, SC ;

AGUILAR, S ;

MEYER, PR ;

KRAILO, M ;

PARKER, J ;

RASHEED, S .

ANNALS OF INTERNAL MEDICINE, 1986, 105 (01) :32-37

[10] EVIDENCE THAT A CAPPED OLIGORIBONUCLEOTIDE IS THE PRIMER FOR DUCK HEPATITIS-B VIRUS PLUS-STRAND DNA-SYNTHESIS [J].

LIEN, JM ;

ALDRICH, CE ;

MASON, WS .

JOURNAL OF VIROLOGY, 1986, 57 (01) :229-236

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