Update on genetics and diabetic retinopathy

被引：45

作者：

Hampton, Blake M. ^{[1
]}

Schwartz, Stephen G. ^{[1
]}

Brantley, Milam A., Jr. ^{[2
]}

Flynn, Harry W., Jr. ^{[1
]}

机构：

[1] Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, Dept Ophthalmol, 3880 Tamiami Trail North, Naples, FL 34103 USA

[2] Vanderbilt Eye Inst, Dept Ophthalmol, Nashville, TN USA

来源：

CLINICAL OPHTHALMOLOGY | 2015年 / 9卷

关键词：

diabetic retinopathy; genetics; single nucleotide polymorphism; genome-wide association study;

D O I：

10.2147/OPTH.S94508

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Clinical risk factors for diabetic retinopathy (DR), such as duration of disease and degree of glucose control, do not adequately predict disease progression in individual patients, suggesting the presence of a genetic component. Multiple smaller studies have investigated genotype-phenotype correlations in genes encoding vascular endothelial growth factor, aldose reductase, the receptor for advanced glycation end products, and many others. In general, reported results have been conflicting, due to factors including small sample sizes, variations in study design, differences in clinical end points, and underlying genetic differences between study groups. At this time, there is no confirmed association with any risk allele reported. As we continue to collect data from additional studies, the role of genetics in DR may become more apparent.

引用

页码：2175 / 2193

页数：19

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