LACK OF IN VITRO REPAIR OF X-RAY-INDUCED CHAIN BREAKS IN DNA BY POLYNUCLEOTIDE-JOINING ENZYME

被引：38
作者：
KAPP, DS
SMITH, KC
机构：
[1] Department of Radiology, Stanford University School of Medicine, Stanford, CA
来源：
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY AND RELATED STUDIES IN PHYSICS CHEMISTRY AND MEDICINE | 1969年 / 14卷 / 06期
关键词：
D O I：
10.1080/09553006914551741
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The polynucleotide-joining enzyme does not repair (in one step) the single-strand chain breaks produced in DNA by x-irradiation in aqueous media. Preliminary data on the chemical nature of the ends of the broken strands suggest that nuclease action (to 'clean' the termini), followed by polymerase action, is necessary before the irradiated DNA would become a substrate for the polynucleotide-joining enzyme. © 1969 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：567 / &
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