A POTENTIAL VULNERABILITY LOCUS FOR SCHIZOPHRENIA ON CHROMOSOME 6P24-22 - EVIDENCE FOR GENETIC-HETEROGENEITY

被引：394

作者：

STRAUB, RE

MACLEAN, CJ

ONEILL, FA

BURKE, J

MURPHY, B

DUKE, F

SHINKWIN, R

WEBB, BT

ZHANG, J

WALSH, D

KENDLER, KS

机构：

[1] VIRGINIA COMMONWEALTH UNIV, DEPT PSYCHIAT, RICHMOND, VA 23298 USA

[2] VIRGINIA COMMONWEALTH UNIV, HUMAN GENET MED COLL VIRGINIA, RICHMOND, VA 23298 USA

[3] QUEENS UNIV BELFAST, DEPT PSYCHIAT, BELFAST, ANTRIM, NORTH IRELAND

[4] HLTH RES BOARD, DUBLIN, IRELAND

来源：

NATURE GENETICS | 1995年 / 11卷 / 03期

关键词：

D O I：

10.1038/ng1195-287

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In 265 Irish pedigrees, with linkage analysis we find evidence for a vulnerability locus for schizophrenia in region 6p24-22. The greatest lod score, assuming locus heterogeneity, is 3.51 (P = 0.0002) with D6S296. Another test, the C test, also supported linkage, the strongest results being obtained with D6S296 (P = 0.00001), D6S274 (P = 0.004) and D6S285 (P = 0.006). Non-parametric analysis yielded suggestive, but substantially weaker, findings. This locus appears to influence the vulnerability to schizophrenia in roughly 15 to 30% of our pedigrees. Evidence for linkage was maximal using an intermediate phenotypic definition and declined when this definition was narrowed or was broadened to include other psychiatric disorders.

引用

页码：287 / 293

页数：7

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