THIOALKYLATION OF NUCLEOSIDE-H-PHOSPHONATES AND ITS APPLICATION TO SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDES

被引：10

作者：

BRILL, WKD

机构：

[1] Central Research Laboratories of Ciba-Geigy, CH-4002 Basle

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 05期

关键词：

D O I：

10.1016/0040-4039(94)02380-T

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile method for the thioalkylation of H-phosphonate diesters is presented. It can be used in the solid phase synthesis of oligonucleotides according to the H-phosphonate method.

引用

页码：703 / 706

页数：4

共 15 条

[1] AGRAWAL S, 1990, TETRAHEDRON LETT, V52, P7541
[2] ADVANCES IN THE SYNTHESIS OF OLIGONUCLEOTIDES BY THE PHOSPHORAMIDITE APPROACH
BEAUCAGE, SL
IYER, RP
[J]. TETRAHEDRON, 1992, 48 (12) : 2223 - 2311
[3] FACILE METHODS TO RECYCLE NUCLEOSIDES DURING SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDES
BRILL, WKD
[J]. TETRAHEDRON LETTERS, 1994, 35 (19) : 3041 - 3044
[4] SYNTHESIS AND P-DIASTEREOMERIC RESOLUTION OF NUCLEOSIDE 3'-O(S-ALKYL) AND NUCLEOSIDE 3'-O(S-ARYL) METHYLPHOSPHONOTHIOATES
BRILL, WKD
CARUTHERS, MH
[J]. TETRAHEDRON LETTERS, 1988, 29 (11) : 1227 - 1230
[5] DEVROOM E, 1988, RECL TRAV CHIM PAY B, V107, P592
[6] DEVROOM E, 1987, RECL TRAV CHIM PAY B, V108, P65
[7] DREEF CE, 1990, SYNLETT, P481
[8] DEOXYNUCLEOSIDE H-PHOSPHONATE DIESTER INTERMEDIATES IN THE SYNTHESIS OF INTERNUCLEOTIDE PHOSPHATE ANALOGS
FROEHLER, BC
[J]. TETRAHEDRON LETTERS, 1986, 27 (46) : 5575 - 5578
[9] A NEW APPROACH TO THE SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES WITH ALKYLAMINO GROUPS LINKED TO INTERNUCLEOTIDE PHOSPHATE GROUPS
GRYAZNOV, SM
POTAPOV, VK
[J]. TETRAHEDRON LETTERS, 1991, 32 (30) : 3715 - 3718
[10] H-PHOSPHONATE DNA-SYNTHESIS WITHOUT AMINO PROTECTION
KUNG, PP
JONES, RA
[J]. TETRAHEDRON LETTERS, 1992, 33 (40) : 5869 - 5872

← 1 2 →