PERSONALITY-CHARACTERISTICS, PSYCHOENDOCRINOLOGICAL STRESS AND OUTCOME OF IVF DEPEND UPON THE ETIOLOGY OF INFERTILITY

被引:43
作者
DEMYTTENAERE, K
NIJS, P
EVERSKIEBOOMS, G
KONINCKX, PR
机构
[1] Department of Psychiatry, Center for Human Genetics
[2] Center for Human Genetics
[3] Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Catholic University of Leuven
关键词
IN-VITRO FERTILIZATION; PSYCHOENDOCRINOLOGY; TRAIT ANXIETY; STATE ANXIETY; SUBTLE CYCLE DISTURBANCES;
D O I
10.3109/09513599409023626
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Personality characteristics, psychoendocrinological stress responses and course and outcome of treatment were investigated in 40 women undergoing in vitro fertilization (IVF). In addition to classification by the major causes of infertility (mechanical infertility or male infertility), the subjects were also divided in two subgroups of 17 women with completely 'normal' menstural cycles and 23 women with subtle disturbances of their menstrual cycle. These disturbances were due to either minimal endometriosis, luteinized unruptured follicle (LUF) syndrome or luteal phase insufficiency. Women with subtle cycle disturbances have been shown to have a lower pregnancy rate in IVF than women with normal cycles. The correlation of the state anxiety level of the patient in the early follicular phase with a negative outcome in IVF is seen to be higher in women with subtle cycle disturbances. Furthermore, prolactin concentrations are always higher in women with subtle cycle disturbances. Our data contribute to the hypothesis that subtle cycle disturbances, i.e. LUF syndrome, luteal phase insufficiency and endometriosis, could be associated with higher psychoendocrinological stress levels.
引用
收藏
页码:233 / 240
页数:8
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  • [1] Mahadevan M.M., Trounson A.O., Leeton J.F., The relationship of tubal blockage, infertility of unknown cause, suspected male infertility, and endometriosis to success of in vitro fertilization and embryo transfer, Fertil. Steril., 40, pp. 755-762, (1983)
  • [2] Pepperell R.J., McBain J.C., Unexplained infertility: a review, Br. J. Obstet. Gynaecol., 92, pp. 569-580, (1985)
  • [3] Sarrel P.M., DeCherney A.H., Psychotherapeutic interventions for treatment of couples with secondary infertility, Fertil. Steril., 43, pp. 897-900, (1985)
  • [4] Demyttenaere K., Nijs P., Steeno O., Konmckx P.R., Evers-Kiebooms G., Anxiety and conception rates in donor insemination, J. Psychosom. Obstet. Gynaecol., 8, pp. 175-181, (1988)
  • [5] Nijs P., Koninckx P.R., Verstraeten D., Mullens A., Nicazy H., Psychological factors of female infertility, Eur. J. Obstet. Gynecol. Reprod. Biol., 18, pp. 375-379, (1984)
  • [6] Pesch U., Weyer G., Taubert H.D., Coping mechanisms in infertile women with luteal phase deficiency, J. Psychosom. Obstet. Gynaecol., 10, pp. 15-19, (1989)
  • [7] Koninckx P.R., Sole P., Van DenBroucke W., Brosens I., New aspects of the pathophysiology of endometriosis and associated infertility, J. Reprod. Med., 24, pp. 257-260, (1980)
  • [8] Board J.A., Storlazzi E., Schneider V., Nocturnal prolactin levels in infertility, Fertil. Steril., 36, pp. 720-724, (1981)
  • [9] Radwanska E., Henig J., Dmowski W.P., Nocturnal prolactin levels in infertile women with endometriosis, J. Reprod. Med., 32, pp. 605-608, (1987)
  • [10] Demyttenaere K., Nijs P., Evers-Kiebooms G., Koninckx P.R., The effect of a specific emotional stressor on prolactin, Cortisol, and testosterone concentrations in women varies with their trait anxiety, Fertil. Steril., 52, pp. 942-948, (1989)