REGULATION OF PROTEIN-TYROSINE KINASES IN PLATELETS

被引：157

作者：

CLARK, EA ^{[1
]}

SHATTIL, SJ ^{[1
]}

BRUGGE, JS ^{[1
]}

机构：

[1] UNIV PENN,SCH MED,DEPT MED,PHILADELPHIA,PA 19104

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 11期

关键词：

D O I：

10.1016/0968-0004(94)90131-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Platelet activation is accompanied by a dramatic increase in tyrosine phosphorylation of many cellular proteins. Phosphorylation of these proteins occurs in successive waves during the activation process, suggesting that several distinct mechanisms, occurring in a temporal order, regulate protein tyrosine kinases and/or phosphatases in activated platelets. Several tyrosine kinases, including Src family kinases, Syk and FAK, have been implicated in these phosphorylation events. These kinases are regulated by distinct receptor-mediated events involving activation of their catalytic activity and alterations in their cellular localization.

引用

页码：464 / 469

页数：6

共 44 条

[1] THE SRC FAMILY OF TYROSINE PROTEIN-KINASES IN HEMATOPOIETIC SIGNAL TRANSDUCTION [J].