SYNTHESIS OF ALPHA-(AMINOMETHYLENE)-9-(METHOXYMETHYL)-9H-PURINE-6-ACETIC ACID-DERIVATIVES

被引：8

作者：

HAMAMICHI, N

MIYASAKA, T

机构：

[1] School of Pharmaceutical Sciences, Showa University, Tokyo, 142, Hatanodai 1-5-8, Shinagawa-ku

[2] Department of Chemistry, University of Virginia, Charlottesville, Virginia, 22901, McCormick Road

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 07期

关键词：

D O I：

10.1002/jhet.5570270731

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-(Aminomethylene)-9-(methoxymethyl)-9H-purine-6-acetamide and the ethyl acetate, 3 and 8, have been synthesized by catalytic hydrogenation of 6-cyanomethylene-9-methoxymethylpurine derivatives 2 and 7 which were obtained by the substitution of 6-chloro-9-(methoxymethyl)purine (1) with alpha-cyanoacetamide and ethyl cyanoacetate, respectively. Substitution of 3 and 8 with amines gave the corresponding N-substituted alpha-(aminomethylene)-9-(methoxymethyl)-9H-purine-6-acetamide and the ethyl acetate 4 and 10. Reaction of 3 with piperidine gave 9-(methoxymethyl)-9H-purine-6-acetamide (5).

引用

页码：2011 / 2015

页数：5

共 16 条

[1] SPECTRAL PROPERTIES AND ISOMERISM OF NITROENAMINES .1. 3-AMINO-2-NITRO-ACRYLIC ESTERS [J].