SYNTHESIS OF ALPHA-(AMINOMETHYLENE)-9-(METHOXYMETHYL)-9H-PURINE-6-ACETIC ACID-DERIVATIVES

被引：8
作者：
HAMAMICHI, N
MIYASAKA, T
机构：
[1] School of Pharmaceutical Sciences, Showa University, Tokyo, 142, Hatanodai 1-5-8, Shinagawa-ku
[2] Department of Chemistry, University of Virginia, Charlottesville, Virginia, 22901, McCormick Road
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 07期
关键词：
D O I：
10.1002/jhet.5570270731
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
alpha-(Aminomethylene)-9-(methoxymethyl)-9H-purine-6-acetamide and the ethyl acetate, 3 and 8, have been synthesized by catalytic hydrogenation of 6-cyanomethylene-9-methoxymethylpurine derivatives 2 and 7 which were obtained by the substitution of 6-chloro-9-(methoxymethyl)purine (1) with alpha-cyanoacetamide and ethyl cyanoacetate, respectively. Substitution of 3 and 8 with amines gave the corresponding N-substituted alpha-(aminomethylene)-9-(methoxymethyl)-9H-purine-6-acetamide and the ethyl acetate 4 and 10. Reaction of 3 with piperidine gave 9-(methoxymethyl)-9H-purine-6-acetamide (5).
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页码：2011 / 2015
页数：5
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