P-GLYCOPROTEIN AND DRUG-RESISTANCE IN ACUTE LEUKEMIAS AND IN THE BLASTIC CRISIS OF CHRONIC MYELOID-LEUKEMIA

被引：0

作者：

CARULLI, G

PETRINI, M

MARINI, A

VAGLINI, F

CARACCIOLO, F

GRASSI, B

机构：

[1] UNIV PISA,MED CLIN 1,UNITA EMATOL,I-56100 PISA,ITALY

[2] UNIV PISA,IST FARMACOL,I-56100 PISA,ITALY

来源：

HAEMATOLOGICA | 1990年 / 75卷 / 06期

关键词：

CHEMORESISTANCE; LEUKEMIA; MULTIDRUG RESISTANCE; P-GLYCOPROTEIN; P-170;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this work is to evaluate the relationship between P-glycoprotein expression in circulating blasts and clinical response in patients suffering from acute lymphoblastic leukemia, acute non-lymphoblastic leukemia, and chronic myeloid leukemia in either lymphoid or myeloid blastic crisis. The results obtained show that: a) patients whose blasts express P-glycoprotein are resistant towards protocols including Doxorubicin, Daunorubicin, Etoposide, Mithramycin, Vincristine; b) P-glycoprotein can be expressed constitutively in some cases; c) P-glycoprotein does not appear to be the only mechanism responsible for resistance towards anthracyclines and Etoposide.

引用

页码：516 / 521

页数：6

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