MK-801 (NONCOMPETITIVE NMDA RECEPTOR ANTAGONIST)-INDUCED BLOCKADE OF THE BURST RESPONSE IN THE DENTATE GYRUS AFTER PERFORANT PATH KINDLING IN ACUTELY PREPARED RABBITS

被引：8

作者：

JIBIKI, I

FUJIMOTO, K

KUBOTA, T

YAMAGUCHI, N

机构：

[1] Department of Neuropsychiatry, Kanazawa University School of Medicine, Kanazawa

来源：

NEUROSCIENCE LETTERS | 1990年 / 116卷 / 1-2期

关键词：

Burst response; Epilepsy; Kindling; MK-801; N-Methyl-d-aspartate receptor antagonist;

D O I：

10.1016/0304-3940(90)90414-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Effects of MK-801, a non-competitive antagonist of N-methyl-d-aspartate (NMDA) receptors, were observed on the 'burst responses' elicited in the dentate gyrus by single shocks to the perforant path after kindling to the pathway in acutely prepared rabbits. The intracortical injection of 10 μM of an MK-801-containing solution almost completely blocked the previously induced burst responses, suggesting that activation of the NMDA receptor or the receptor-linked ion channel greatly contributes to the manifestation of the burst responses. © 1990.

引用

页码：221 / 226

页数：6

共 13 条

[1] EFFECTS OF THE NMDA RECEPTOR CHANNEL ANTAGONISTS CPP AND MK801 ON HIPPOCAMPAL FIELD POTENTIALS AND LONG-TERM POTENTIATION IN ANESTHETIZED RATS [J].