CHARACTERIZATION OF IGD .2. MOLECULAR-FORMS OF IGD IN HUMAN B-CELLS

被引：11

作者：

CORTE, G ^{[1
]}

VIALE, G ^{[1
]}

COSULICH, E ^{[1
]}

BARGELLESI, A ^{[1
]}

FERRARINI, M ^{[1
]}

机构：

[1] UNIV GENOA,CHAIR CLIN IMMUNOL,I-16132 GENOA,ITALY

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1979年 / 10卷 / 03期

关键词：

D O I：

10.1111/j.1365-3083.1979.tb01350.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Endogenous and surface labelling techniques were used on human lymphoid cells to characterize intracytoplasmic, membrane and secreted IgD. IgD synthesized by lymphocytes and inserted into the cell membrane displayed a single molecular form with the same mobiliiy in sodium dodecyl sulphate polyacrylamide gel eleclrophorcsis (SDS‐PAGE) as the previously described slow migrating serum IgDl. Plasma cells produced and secreted IgD1 and another IgD corresponding to the faster‐moving serum IgD2. Conversion of one molecular form into the other was never observed, thus indicating that neither molecule is a precursor or a degradation product of the other. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：275 / 280

页数：6

共 19 条

[1] IGM-PRODUCING TUMORS IN BALB-C MOUSE - MODEL FOR B-CELL MATURATION [J].