DECAY OF VESICULAR STOMATITIS-VIRUS MESSENGER-RNAS INVIVO

被引：21

作者：

PENNICA, D ^{[1
]}

LYNCH, KR ^{[1
]}

COHEN, PS ^{[1
]}

ENNIS, HL ^{[1
]}

机构：

[1] UNIV RHODE ISL,DEPT MICROBIOL,KINGSTON,RI 02881

来源：

VIROLOGY | 1979年 / 94卷 / 02期

关键词：

D O I：

10.1016/0042-6822(79)90480-X

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The stability of vesicular stomatitis virus (VSV) messenger RNA during infection of Chinese hamster ovary (CHO) cells was investigated using the temperature-sensitive mutant, tsG114. By incubating infected cells at the nonpermissive temperature (39°), RNA synthesis was blocked and VSV mRNA decayed rapidly, as determined by sucrose density gradient analysis. Each of the five VSV mRNAs was also found to decay functionally at approximately the same rate suggesting that the differential rates of accumulation of VSV mRNAs observed in vivo are due to differential rates of transcription of specific VSV genes. © 1979.

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页码：484 / 487

页数：4

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