A Review of the Use of Topical Calendula in the Prevention and Treatment of Radiotherapy-Induced Skin Reactions

被引：38
作者：
Kodiyan, Joyson [1 ]
Amber, Kyle T. [2 ]
机构：
[1] Univ Miami, Miller Sch Med, Miami, FL 33136 USA
[2] Macneal Mem Hosp, Dept Med Educ, Berwyn, IL 60402 USA
来源：
ANTIOXIDANTS | 2015年 / 4卷 / 02期
关键词：
radiation induced skin toxicity; calendula; complementary and alternative medicine; radiodermatitis; radiation induced dermatitis; cancer;
D O I：
10.3390/antiox4020293
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Calendula is a topical agent derived from a plant of the marigold family Calendula Officinalis. Containing numerous polyphenolic antioxidants, calendula has been studied in both the laboratory and clinical setting for the use in treating and preventing radiation induced skin toxicity. Despite strong evidence in the laboratory supporting calendula's mechanism of action in preventing radiation induced skin toxicity, clinical studies have demonstrated mixed results. In light of the controversy surrounding the efficacy of calendula in treating and preventing radiodermatitis, the topic warrants further discussion.
引用
收藏
页码：293 / 303
页数：11
相关论文
共 68 条
[1]  
Akhtar N, 2011, ACTA POL PHARM, V68, P693
[2]   Extracts from Calendula officinalis Offer in Vitro Protection Against H2O2 Induced Oxidative Stress Cell Killing of Human Skin Cells [J].
Alnuqaydan, Abdullah M. ;
Lenehan, Claire E. ;
Hughes, Rachel R. ;
Sanderson, Barbara J. .
PHYTOTHERAPY RESEARCH, 2015, 29 (01) :120-124
[3]   The Use of Antioxidants in Radiotherapy-Induced Skin Toxicity [J].
Amber, Kyle T. ;
Shiman, Michael I. ;
Badiavas, Evangelos V. .
INTEGRATIVE CANCER THERAPIES, 2014, 13 (01) :38-45
[4]   Final Report of the Cosmetic Ingredient Review Expert Panel Amended Safety Assessment of Calendula officinalis-Derived Cosmetic Ingredients [J].
Andersen, F. Alan ;
Bergfeld, Wilma F. ;
Belsito, Donald V. ;
Hill, Ronald A. ;
Klaassen, Curtis D. ;
Liebler, Daniel C. ;
Marks, James G., Jr. ;
Shank, Ronald C. ;
Slaga, Thomas J. ;
Snyder, Paul W. .
INTERNATIONAL JOURNAL OF TOXICOLOGY, 2010, 29 :221S-243S
[5]   Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study [J].
Babaee, Neda ;
Moslemi, Dariush ;
Khalilpour, Mohammad ;
Vejdani, Fatemeh ;
Moghadamnia, Yasaman ;
Bijani, Ali ;
Baradaran, Mahmoud ;
Kazemi, Mohammad Taghi ;
Khalilpour, Asieh ;
Pouramir, Mahdi ;
Moghadamnia, Ali Akbar .
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, 2013, 21
[6]   STANDARDIZED TOTAL AVERAGE TOXICITY SCORE: A SCALE- AND GRADE-INDEPENDENT MEASURE OF LATE RADIOTHERAPY TOXICITY TO FACILITATE POOLING OF DATA FROM DIFFERENT STUDIES [J].
Barnett, Gillian C. ;
West, Catharine M. L. ;
Coles, Charlotte E. ;
Pharoah, Paul D. P. ;
Talbot, Christopher J. ;
Elliott, Rebecca M. ;
Tanteles, George A. ;
Symonds, R. Paul ;
Wilkinson, Jennifer S. ;
Dunning, Alison M. ;
Burnet, Neil G. ;
Bentzen, Soren M. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 82 (03) :1065-1074
[7]   IONIZING-RADIATION INDUCES HUMAN INTERCELLULAR-ADHESION MOLECULE-1 IN-VITRO [J].
BEHRENDS, U ;
PETER, RU ;
HINTERMEIERKNABE, R ;
EISSNER, G ;
HOLLER, E ;
BORNKAMM, GW ;
CAUGHMAN, SW ;
DEGITZ, K .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1994, 103 (05) :726-730
[8]  
Bloom R., 2014, POLYPHENOLS FOOD SOU
[9]   Potent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis:: results from a double-blind, randomized study [J].
Boström, Å ;
Lindman, H ;
Swartling, C ;
Berne, B ;
Bergh, J .
RADIOTHERAPY AND ONCOLOGY, 2001, 59 (03) :257-265
[10]   Antioxidant Activity of Calendula officinalis Extract: Inhibitory Effects on Chemiluminescence of Human Neutrophil Bursts and Electron Paramagnetic Resonance Spectroscopy [J].
Braga, Pier Carlo ;
Dal Sasso, Monica ;
Culici, Maria ;
Spallino, Alessandra ;
Falchi, Mario ;
Bertelli, Aldo ;
Morelli, Roberto ;
Lo Scalzo, Roberto .
PHARMACOLOGY, 2009, 83 (06) :348-355
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