DESIGN, SYNTHESIS AND X-RAY CRYSTALLOGRAPHIC STUDIES OF NOVEL FKBP-12 LIGANDS

被引：40

作者：

BABINE, RE

BLECKMAN, TM

KISSINGER, CR

SHOWALTER, R

PELLETIER, LA

LEWIS, C

TUCKER, K

MOOMAW, E

PARGE, HE

VILLAFRANCA, JE

机构：

[1] Agouron Pharmaceuticals, Inc., San Diego, CA 92121-1121

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 15期

关键词：

D O I：

10.1016/0960-894X(95)00290-A

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using the crystal structure of FKBP-12 a novel class of ligands were designed, prepared and evaluated. The crystal structure of the complex between 5 and FKBP-12 is reported.

引用

页码：1719 / 1724

页数：6

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