ANTHELMINTIC ACTIVITY OF DIOXAPYRROLOMYCIN

被引：14

作者：

CONDER, GA ^{[1
]}

ZIELINSKI, RJ ^{[1
]}

JOHNSON, SS ^{[1
]}

KUO, MST ^{[1
]}

COX, DL ^{[1
]}

MARSHALL, VP ^{[1
]}

HABER, CL ^{[1
]}

DIROMA, PJ ^{[1
]}

NELSON, SJ ^{[1
]}

CONKLIN, RD ^{[1
]}

LEE, BL ^{[1
]}

GEARY, TG ^{[1
]}

ROTHWELL, JT ^{[1
]}

SANGSTER, NC ^{[1
]}

机构：

[1] UNIV SYDNEY,DEPT VET PATHOL,SYDNEY,NSW 2006,AUSTRALIA

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 06期

关键词：

D O I：

10.7164/antibiotics.45.977

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Dioxapyrrolomycin, pyrrolomycin C, pyrrolomycin D, and piericidin C2 produced by UC 11065 were evaluated as anthelmintics. Assays used to examine these compounds included effects on the free-living nematode Caenorhabditis elegans, ability to clear target nematodes (Haemonchus contortus and Trichostrongylus colubriformis) from jirds, and clearance of Haemonchus contortus from lambs. A crude extract of UC 11065 containing dioxapyrrolomycin, pyrrolomycin C, pyrrolomycin D, and piericidin C2 was active against C. elegans and against H. contortus in the jird. Purified and/or synthetic samples of dioxapyrrolomycin, pyrrolomycin C, pyrrolomycin D, and piericidin C2 were tested in the jird model; only dioxapyrrolomycin exhibited appreciable activity against H. contortus (greater-than-or-equal-to 90.9% clearance at 0.33 mg/jird), while none of the compounds showed appreciable activity against T. colubriformis. Dioxapyrrolomycin cleared 99.9% of H. contortus from lambs at 12.5 mg/kg. An in vitro migration study using susceptible and closantel-resistant H. contortus showed there is cross-resistance between dioxapyrrolomycin and closantel. Dioxapyrrolomycin appears to be a narrow-spectrum anthelmintic which works through a closantel-like mode-of-action.

引用

页码：977 / 983

页数：7

共 12 条

[1] LL-F42248-ALPHA, A NOVEL CHLORINATED PYRROLE ANTIBIOTIC [J].