RETINOIC ACID DECREASES RETINOIC ACID AND TRIIODOTHYRONINE NUCLEAR RECEPTOR EXPRESSION IN THE LIVER OF HYPERTHYROIDIC RATS

被引：13

作者：

HIGUERET, P ^{[1
]}

PALLET, V ^{[1
]}

COUSTAUT, M ^{[1
]}

AUDOUIN, I ^{[1
]}

BEGUERET, J ^{[1
]}

GARCIN, H ^{[1
]}

机构：

[1] LAB GENET TALENCE, F-33405 TALENCE, FRANCE

来源：

FEBS LETTERS | 1992年 / 310卷 / 02期

关键词：

HYPERTHYROIDISM; RETINOIC ACID; TRIIODOTHYRONINE NUCLEAR RECEPTOR; RETINOIC ACID NUCLEAR RECEPTOR; MESSENGER RNA;

D O I：

10.1016/0014-5793(92)81306-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Retinoic acid (RA) and triiodothyronine (T3) exert many of their actions by binding to specific nuclear receptors (respectively, RA receptor (RAR) and T3) receptor (TR) belonging to a 'superfamily' of receptors. Some heterologous regulation of these receptors has been shown, and in particular regulation of the maximum binding capacity of TR by either retinol or RA. Now, using hyperthyroidic rats as a model, the effect of RA on binding capacity and on the mRNA levels of TR and RAR was investigated. The results show that the benefit of vitamin A treatment for the hyperthyroidic state, which has been described for a long time, could be the result of a down-heteroregulation of TR by RA, the active metabolite of retinol.

引用

页码：101 / 105

页数：5

共 38 条

[21]

MURRAY MB, 1988, J BIOL CHEM, V263, P12770

[22] SEQUENTIAL-CHANGES IN RAT-LIVER NUCLEAR TRI-IODOTHYRONINE RECEPTORS AND MITOCHONDRIAL ALPHA-GLYCEROPHOSPHATE DEHYDROGENASE-ACTIVITY AFTER ADMINISTRATION OF TRI-IODOTHYRONINE [J].